Achieving superhigh sensitivity is the ultimate goal for bio-detection in modern analytical
science and life science. Among variable signal amplification strategies, nucleic acid …

Functional nucleic acids (FNAs), including DNA aptamers and DNAzymes, are finding
increasing use as molecular recognition elements for point-of-care (POC) assays and …

The COVID-19 pandemic has created huge damage to society and brought panic around
the world. Such panic can be ascribed to the seemingly deceptive features of COVID-19 …

Breast cancer is a kind of malignant tumor that mainly appears in the inner lining of milk
ducts, epithelial tissues, or lobules with different degrees of spread, invasiveness, and …

Isothermal nucleic acid amplification techniques have emerged as an important diagnostic
tool for clinical applications and food safety inspection. Rolling circle amplification (RCA) is …

The combination of nanostructures with biomolecules leading to the generation of functional
nanosystems holds great promise for biotechnological and biomedical applications. As a …

Multiplexed detection of extracellular vesicle (EV)-derived microRNAs (miRNAs) plays a
critical role in facilitating disease diagnosis and prognosis evaluation. Herein, we developed …

Rolling circle amplification (RCA) is an isothermal enzymatic process where a short DNA or
RNA primer is amplified to form a long single stranded DNA or RNA using a circular DNA …

Isothermal exponential amplification techniques, such as strand‐displacement amplification
(SDA), rolling circle amplification (RCA), loop‐mediated isothermal amplification (LAMP) …

DNAzymes have been recognized as promising transducing agents for visualizing
endogenous biomarkers, but their inefficient intracellular delivery and limited amplification …