Over the past decade, CRISPR has become as much a verb as it is an acronym,
transforming biomedical research and providing entirely new approaches for dissecting all …

Based on engineered or bacterial nucleases, the development of genome editing
technologies has opened up the possibility of directly targeting and modifying genomic …

Drug-tolerant persister cells (persisters) evade apoptosis upon targeted and conventional
cancer therapies and represent a major non-genetic barrier to effective cancer treatment …

Summary Apolipoprotein E4 (APOE4) is the greatest known genetic risk factor for
developing sporadic Alzheimer's disease. How the interaction of APOE4 microglia with …

Posttranslational modifications of histones (PTMs) are associated with specific chromatin
and gene expression states,. Although studies in Drosophila melanogaster have revealed …

At present, the idea of genome modification has revolutionized the modern therapeutic
research era. Genome modification studies have traveled a long way from gene …

Gene therapy has long held promise to correct a variety of human diseases and defects.
Discovery of the Clustered Regularly-Interspaced Short Palindromic Repeats (CRISPR), the …

There is a growing body of evidence that therapy-related myeloid neoplasms (t-MNs) with
driver gene mutations arise in the background of clonal hematopoiesis (CH) under the …

The CRISPR-Cas9 RNA-guided DNA endonuclease has contributed to an explosion of
advances in the life sciences that have grown from the ability to edit genomes within living …

The CRISPR-Cas9 genome-editing system is a part of the adaptive immune system in
archaea and bacteria to defend against invasive nucleic acids from phages and plasmids …