[HTML][HTML] Advances in our understanding of oxylipins derived from dietary PUFAs

M Gabbs, S Leng, JG Devassy, M Monirujjaman… - Advances in …, 2015 - Elsevier
Oxylipins formed from polyunsaturated fatty acids (PUFAs) are the main mediators of PUFA
effects in the body. They are formed via cyclooxygenase, lipoxygenase, and cytochrome …

Essential fatty acids as functional components of foods-a review

N Kaur, V Chugh, AK Gupta - Journal of food science and technology, 2014 - Springer
During the recent decades, awareness towards the role of essential fatty acids in human
health and disease prevention has been unremittingly increasing among people. Fish, fish …

Omega-3 polyunsaturated fatty acids protect against inflammation through production of LOX and CYP450 lipid mediators: relevance for major depression and for …

A Borsini, A Nicolaou, D Camacho-Muñoz… - Molecular …, 2021 - nature.com
Eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) can exert antidepressant,
anti-inflammatory and neuroprotective properties, but the exact molecular mechanism …

The human serum metabolome

N Psychogios, DD Hau, J Peng, AC Guo, R Mandal… - PloS one, 2011 - journals.plos.org
Continuing improvements in analytical technology along with an increased interest in
performing comprehensive, quantitative metabolic profiling, is leading to increased interest …

Omega-3 fatty acids and cardiovascular disease: effects on risk factors, molecular pathways, and clinical events

D Mozaffarian, JHY Wu - Journal of the American College of Cardiology, 2011 - jacc.org
We reviewed available evidence for cardiovascular effects of n-3 polyunsaturated fatty acid
(PUFA) consumption, focusing on long chain (seafood) n-3 PUFA, including their principal …

Therapeutic potential of omega-3 fatty acid-derived epoxyeicosanoids in cardiovascular and inflammatory diseases

WH Schunck, A Konkel, R Fischer… - Pharmacology & …, 2018 - Elsevier
Numerous benefits have been attributed to dietary long-chain omega-3 polyunsaturated fatty
acids (n-3 LC-PUFAs), including protection against cardiac arrhythmia, triglyceride-lowering …

[HTML][HTML] (n-3) fatty acids and cardiovascular health: are effects of EPA and DHA shared or complementary?

D Mozaffarian, JHY Wu - The Journal of nutrition, 2012 - Elsevier
Considerable research supports cardiovascular benefits of consuming omega-3 PUFA, also
known as (n-3) PUFA, from fish or fish oil. Whether individual long-chain (n-3) PUFA have …

Cytochrome P450 epoxygenase pathway of polyunsaturated fatty acid metabolism

AA Spector, HY Kim - Biochimica et Biophysica Acta (BBA)-Molecular and …, 2015 - Elsevier
Polyunsaturated fatty acids (PUFA) are oxidized by cytochrome P450 epoxygenases to
PUFA epoxides which function as potent lipid mediators. The major metabolic pathways of …

Fish oil—how does it reduce plasma triglycerides?

GC Shearer, OV Savinova, WS Harris - … BBA)-Molecular and Cell Biology of …, 2012 - Elsevier
Long chain omega-3 fatty acids (FAs) are effective for reducing plasma triglyceride (TG)
levels. At the pharmaceutical dose, 3.4 g/day, they reduce plasma TG by about 25–50% after …

Epoxy metabolites of docosahexaenoic acid (DHA) inhibit angiogenesis, tumor growth, and metastasis

G Zhang, D Panigrahy, LM Mahakian… - Proceedings of the …, 2013 - National Acad Sciences
Epidemiological and preclinical evidence supports that omega-3 dietary fatty acids (fish oil)
reduce the risks of macular degeneration and cancers, but the mechanisms by which these …