Due to its complex and multifaceted nature, developing effective treatments for epilepsy is
still a major challenge. To deal with this complexity we introduce the concept of degeneracy …

The sensory inflow from the periphery that triggers innocuous and painful sensations is
highly complex, capturing key elements of the nature of any stimulus, its location, intensity …

The need for reproducible, credible, multiscale biological modeling has led to the
development of standardized simulation platforms, such as the widely-used NEURON …

Parvalbumin-expressing interneurons (PVINs) play a crucial role within the dorsal horn of
the spinal cord by preventing touch inputs from activating pain circuits. In both male and …

Seventy years ago, Hodgkin and Huxley published the first mathematical model to describe
action potential generation, laying the foundation for modern computational neuroscience …

Sensory feedback is integral for contextually appropriate motor output, yet the neural circuits
responsible remain elusive. Here, we pinpoint the medial deep dorsal horn of the mouse …

Neurons encounter unavoidable evolutionary trade-offs between multiple tasks. They must
consume as little energy as possible while effectively fulfilling their functions. Cells …

The primary somatosensory cortex (S1) of mammals is critically important in the perception
of touch and related sensorimotor behaviors. In 2015, the Blue Brain Project (BBP) …

The spinal dorsal horn (DH) processes sensory information and plays a key role in
transmitting nociception to supraspinal centers. Loss of DH inhibition during neuropathic …

Spinal cord dorsal horn inhibition is critical to the processing of sensory inputs, and its
impairment leads to mechanical allodynia. How this decreased inhibition occurs and …