Target identification is an important step in drug discovery, and computer-aided drug target
identification methods are attracting more attention compared with traditional drug target …

Understanding molecular mechanisms underlying the complexity of allosteric regulation in
proteins has attracted considerable attention in drug discovery due to the benefits and …

Infections caused by malaria parasites place an enormous burden on the world's poorest
communities. Breakthrough drugs with novel mechanisms of action are urgently needed. As …

Development of antimalarial compounds into clinical candidates remains costly and arduous
without detailed knowledge of the target. As resistance increases and treatment options at …

Antimalarial drug discovery has until recently been driven by high‐throughput phenotypic
cellular screening, allowing millions of compounds to be assayed and delivering clinical …

Abstract Background South African Natural Compounds Database (SANCDB; https://sancdb.
rubi. ru. ac. za/) is the sole and a fully referenced database of natural chemical compounds …

Highlights•In-vitro evolution and whole genome sequencing elucidates gene–drug
interactions.•Cellular thermal shift assay and mass spectrometry directly reveals small …

Due to side-effects and inefficiency of the drugs used in malaria treatment, finding alternative
medicine with less side-effects has attracted much attention. In this regard, in the present …

BACKGROUND Glutathione transferases (GSTs) are enzymes with a wide range of
functions, including herbicide detoxification. Up‐regulation of GSTs and their detoxification …

Malaria is a parasitic illness caused by the genus Plasmodium from the apicomplexan
phylum. Five plasmodial species of P. falciparum (Pf), P. knowlesi, P. malariae, P. ovale, and …