The skin is one of the most essential organs in the human body, interacting with the external
environment and shielding the body from diseases and excessive water loss. Thus, the loss …

Repair following injury involves a range of processes–such as re-epithelialization, scar
formation, angiogenesis, inflammation, and more–that function, often together, to restore …

The skin provides the primary protection for the body against external injuries and is
essential in the maintenance of general homeostasis. During ageing, resident cells become …

To provide a stable environmental barrier, the epidermis requires an integrated network of
cytoskeletal elements and cellular junctions. Nevertheless, the epidermis ranks among the …

The integrin family of transmembrane adhesion receptors is essential for sensing and
adhering to the extracellular environment. Integrins are heterodimers composed of non …

Integrin α6β4 is a cellular adhesion molecule that binds to laminins in the extracellular
matrix and nucleates the formation of hemidesmosomes. During carcinoma progression …

Intermediate filaments are assembled from a diverse group of evolutionary conserved
proteins and are specified in a tissue-dependent, cell type-dependent, and context …

Although a host of intracellular signals is known to contribute to wound healing, the role of
the cell microenvironment in tissue repair remains elusive. Here we employed 2 different …

The percutaneous device dilemma describes etiological factors, centered around the
disrupted epithelial tissue surrounding non-remodelable devices, that contribute to rampant …

Hemidesmosomes are specialized cell-matrix adhesion structures that are associated with
the keratin cytoskeleton. Although the adhesion function of hemidesmosomes has been …