Anti-tumorigenic mechanisms mediated by the tumor suppressor p53, upon oncogenic
stresses, are our bodies' greatest weapons to battle against cancer onset and development …

Simple Summary The p53 pathway is a major tumor suppressor pathway that prevents the
propagation of abnormal cells by regulating DNA repair, cell cycle progression, cell death, or …

T-cell exhaustion in cancer is linked to poor clinical outcomes, where evidence suggests T-
cell metabolic changes precede functional exhaustion. Direct competition between tumor …

It has been reported that abnormal epigenetic modification is associated with the occurrence
of Parkinson's disease (PD). Here, we found that a ten-eleven translocation 2 (TET2), a staff …

Tumorigenesis can be induced by various stresses that cause aberrant DNA mutations and
unhindered cell proliferation. Under such conditions, normal cells autonomously induce …

ARF role as tumor suppressor has been challenged in the last years by several findings of
different groups ultimately showing that its functions can be strictly context dependent. We …

Objective Genetic alterations in CDKN2A tumor suppressor gene on chromosome 9p21
confer a predisposition to childhood acute lymphoblastic leukemia (ALL). Genome-wide …

Cancer genome sequencing has identified dozens of mutations with a putative role in
lymphomagenesis and leukemogenesis. Validation of driver mutations responsible for B cell …

The p53 pathway is functionally inactivated in most, if not all, human cancers. The p53
protein is a central effector of numerous stress-related molecular cascades. p53 controls a …

2023-09-01 Assigned to UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION
reassignment UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION ASSIGNMENT OF …