Increasing evidence supports a central role of the immune system in sepsis, but the current
view of how sepsis affects immunity, and vice versa, is still rudimentary. The European …

Interleukin-10 (IL-10), first recognized for its ability to inhibit activation and effector function of
T cells, monocytes, and macrophages, is a multifunctional cytokine with diverse effects on …

Sepsis is a constellation of clinical signs and symptoms resulting from excessive systemic
host inflammatory response to infection. This inflammatory response is largely mediated by …

Objective: A prospective study to investigate the pattern of proinflammatory and anti-
inflammatory cytokine responses in preterm infants with systemic infection. Methods: Very …

The most severe forms of COVID-19 share many features with bacterial sepsis and have
thus been considered to be a viral sepsis. Innate immunity and inflammation are closely …

Objective. To investigate whether the determination of serum procalcitonin (PCT) in systemic
autoimmune disease will help to discriminate invasive infection from highly active underlying …

Abstract Interleukin (IL)-10 is a pleiotropic cytokine produced by both T cells and
macrophages and possesses both anti-inflammatory and immunosuppressive properties. IL …

Objective To quantify the sequential changes in metabolic response occurring in patients
with severe sepsis after the onset of peritonitis. Summary Background Data Understanding …

Publisher Summary This chapter reviews the role of cytokines in the pathogenesis of sepsis.
The various models for sepsis are also discussed, including the human models and animal …

Pro-inflammatory and anti-inflammatory cytokines are important mediators in the host
response to infection. In contrast to the pro-inflammatory cytokines little is known about anti …