The worldwide upward trend in obesity has been dramatic, now affecting more than 20% of
American women of reproductive age. Obesity is associated with many adverse maternal …

BACKGROUND Advanced maternal age is associated with decreased oocyte quantity and
quality as well as uterine and placental dysfunctions. These changes lead to infertility …

The oocyte is recognised as the largest cell in mammalian species and other multicellular
organisms. Mitochondria represent a high proportion of the cytoplasm in oocytes and …

BACKGROUND There is a great inter-individual variability of ovarian ageing, and almost
20% of patients consulting for infertility show signs of premature ovarian ageing. This …

Mitochondrial dysfunction is one of the hallmarks of aging. Consistently mitochondrial DNA
(mtDNA) copy number and function decline with age in various tissues. There is increasing …

Background Management of women with reduced ovarian reserve or poor ovarian response
(POR) to stimulation is one of the major challenges in reproductive medicine. The primary …

Optimal energy production is required for oocyte and embryo development, and
mitochondrial abnormalities have devastating reproductive consequences. Improvement of …

Background A couple may be considered to have fertility problems if they have been trying
to conceive for over a year with no success. This may affect up to a quarter of all couples …

Primary ovarian insufficiency (POI) is a rare gynecological condition. This disease causes
menstrual disturbances, infertility, and various health problems. Historically, hormone …

Objective To investigate the clinical relevance of mitochondrial DNA (mtDNA) content as a
viability score in human euploid embryos. Design Retrospective analysis of mtDNA content …