Advances in screening of thalassaemia
J Gao, W Liu - Clinica Chimica Acta, 2022 - Elsevier
Thalassaemia is a common hereditary haemolytic anaemia. Mild cases of this disease may
be asymptomatic, while patients with severe thalassaemias require high-dose blood …
be asymptomatic, while patients with severe thalassaemias require high-dose blood …
[HTML][HTML] Nrf2 expands the intracellular pool of the chaperone AHSP in a cellular model of β-thalassemia
G Han, C Cao, X Yang, GW Zhao, XJ Hu, DL Yu… - Redox biology, 2022 - Elsevier
In β-thalassemia, free α-globin chains are unstable and tend to aggregate or degrade,
releasing toxic heme, porphyrins and iron, which produce reactive oxygen species (ROS). α …
releasing toxic heme, porphyrins and iron, which produce reactive oxygen species (ROS). α …
[HTML][HTML] Iron chelation therapy with deferiprone improves oxidative status and red blood cell quality and reduces redox-active iron in β-thalassemia/hemoglobin E …
NP Morales, S Rodrat, P Piromkraipak… - Biomedicine & …, 2022 - Elsevier
The oxidative status of twenty-three β-thalassemia/hemoglobin E patients was evaluated
after administration of 75 mg/kg deferiprone (GPO-L-ONE®) divided into 3 doses daily for 12 …
after administration of 75 mg/kg deferiprone (GPO-L-ONE®) divided into 3 doses daily for 12 …
The crucial role of NRF2 in erythropoiesis and anemia: Mechanisms and therapeutic opportunities
L Yang, Y Chen, S He, D Yu - Archives of Biochemistry and Biophysics, 2024 - Elsevier
The nuclear factor erythroid 2-related factor 2 (NRF2) is a transcription factor crucial in
cellular defense against oxidative and electrophilic stresses. Recent research has …
cellular defense against oxidative and electrophilic stresses. Recent research has …
MicroRNA-92a-3p-mediated inhibition of BCL11A upregulates γ-globin expression and inhibits oxidative stress and apoptosis in erythroid precursor cells
H Li, R Lin, H Li, R Ou, K Wang, J Lin, C Li - Hematology, 2022 - Taylor & Francis
Objective This study attempted to investigate miR-92a-3p expression in peripheral blood of
patients with severe β-thalassemia, and the effect and action mechanism of miR-92a-3p on γ …
patients with severe β-thalassemia, and the effect and action mechanism of miR-92a-3p on γ …
Diagnosis of systemic diseases using infrared spectroscopy: detection of iron overload in plasma—preliminary study
LB Leal, MS Nogueira, JGA Mageski, TP Martini… - … Trace Element Research, 2021 - Springer
Despite the important role of iron in cellular homeostasis, iron overload (IO) is associated
with systemic and tissue deposits which damage several organs. In order to reduce the …
with systemic and tissue deposits which damage several organs. In order to reduce the …
Label-free digital holotomography reveals ibuprofen-induced morphological changes to red blood cells
Understanding the dose-dependent effect of over-the-counter drugs on red blood cells
(RBCs) is crucial for hematology and digital pathology. Yet, it is challenging to continuously …
(RBCs) is crucial for hematology and digital pathology. Yet, it is challenging to continuously …
Enhancing thalassemia gene carrier identification in non‐anemic populations using artificial intelligence erythrocyte morphology analysis and machine learning
F Zhang, J Zhan, Y Wang, J Cheng… - European Journal of …, 2024 - Wiley Online Library
Background Non‐anemic thalassemia trait (TT) accounted for a high proportion of TT cases
in South China. Objective To use artificial intelligence (AI) analysis of erythrocyte …
in South China. Objective To use artificial intelligence (AI) analysis of erythrocyte …
Platelet thrombus formation by upstream activation and downstream adhesion of platelets in a microfluidic system
Platelet activation causes platelet aggregation and their adhesion to the vascular wall. In the
circulatory environment, platelet activation and adhesion might not occur at the same site. In …
circulatory environment, platelet activation and adhesion might not occur at the same site. In …
METTL16 participates in haemoglobin H disease through m6A modification
Y Liao, F Zhang, F Yang, S Huang, S Su, X Tan… - PloS one, 2024 - journals.plos.org
Background Haemoglobin H (HbH) disease is caused by a disorder of α-globin synthesis,
and it results in a wide range of clinical symptoms. M6A methylation modification may be …
and it results in a wide range of clinical symptoms. M6A methylation modification may be …