Thalassaemia is a common hereditary haemolytic anaemia. Mild cases of this disease may
be asymptomatic, while patients with severe thalassaemias require high-dose blood …

In β-thalassemia, free α-globin chains are unstable and tend to aggregate or degrade,
releasing toxic heme, porphyrins and iron, which produce reactive oxygen species (ROS). α …

The oxidative status of twenty-three β-thalassemia/hemoglobin E patients was evaluated
after administration of 75 mg/kg deferiprone (GPO-L-ONE®) divided into 3 doses daily for 12 …

The nuclear factor erythroid 2-related factor 2 (NRF2) is a transcription factor crucial in
cellular defense against oxidative and electrophilic stresses. Recent research has …

Objective This study attempted to investigate miR-92a-3p expression in peripheral blood of
patients with severe β-thalassemia, and the effect and action mechanism of miR-92a-3p on γ …

Despite the important role of iron in cellular homeostasis, iron overload (IO) is associated
with systemic and tissue deposits which damage several organs. In order to reduce the …

Understanding the dose-dependent effect of over-the-counter drugs on red blood cells
(RBCs) is crucial for hematology and digital pathology. Yet, it is challenging to continuously …

Background Non‐anemic thalassemia trait (TT) accounted for a high proportion of TT cases
in South China. Objective To use artificial intelligence (AI) analysis of erythrocyte …

Platelet activation causes platelet aggregation and their adhesion to the vascular wall. In the
circulatory environment, platelet activation and adhesion might not occur at the same site. In …

Background Haemoglobin H (HbH) disease is caused by a disorder of α-globin synthesis,
and it results in a wide range of clinical symptoms. M6A methylation modification may be …