Ruthenium complexes in the fight against pathogenic microorganisms. An extensive review

AC Munteanu, V Uivarosi - Pharmaceutics, 2021 - mdpi.com
The widespread use of antibiotics has resulted in the emergence of drug-resistant
populations of microorganisms. Clearly, one can see the need to develop new, more …

Role of carbon monoxide in host–gut microbiome communication

CP Hopper, LK De La Cruz, KV Lyles… - Chemical …, 2020 - ACS Publications
Nature is full of examples of symbiotic relationships. The critical symbiotic relation between
host and mutualistic bacteria is attracting increasing attention to the degree that the gut …

Bacterial Oxidases of the Cytochrome bd Family: Redox Enzymes of Unique Structure, Function, and Utility As Drug Targets

VB Borisov, SA Siletsky, A Paiardini… - Antioxidants & redox …, 2021 - liebertpub.com
Significance: Cytochrome bd is a ubiquinol: oxygen oxidoreductase of many prokaryotic
respiratory chains with a unique structure and functional characteristics. Its primary role is to …

[HTML][HTML] A thiol-reactive Ru (II) ion, not CO release, underlies the potent antimicrobial and cytotoxic properties of CO-releasing molecule-3

HM Southam, TW Smith, RL Lyon, C Liao, CR Trevitt… - Redox biology, 2018 - Elsevier
Carbon monoxide (CO)-releasing molecules (CORMs), mostly metal carbonyl compounds,
are extensively used as experimental tools to deliver CO, a biological 'gasotransmitter', in …

'Carbon-monoxide-releasing molecule-2 (CORM-2)'is a misnomer: ruthenium toxicity, not CO release, accounts for its antimicrobial effects

HM Southam, MP Williamson, JA Chapman, RL Lyon… - Antioxidants, 2021 - mdpi.com
Carbon monoxide (CO)-releasing molecules (CORMs) are used to deliver CO, a biological
'gasotransmitter', in biological chemistry and biomedicine. CORMs kill bacteria in culture and …

The microbiology of ruthenium complexes

HM Southam, JA Butler, JA Chapman… - Advances in microbial …, 2017 - Elsevier
Ruthenium is seldom mentioned in microbiology texts, due to the fact that this metal has no
known, essential roles in biological systems, nor is it generally considered toxic. Since the …

Do nitric oxide, carbon monoxide and hydrogen sulfide really qualify as 'gasotransmitters' in bacteria?

LK Wareham, HM Southam… - Biochemical Society …, 2018 - portlandpress.com
A gasotransmitter is defined as a small, generally reactive, gaseous molecule that, in
solution, is generated endogenously in an organism and exerts important signalling roles. It …

Recent advances on carbon monoxide releasing molecules for antibacterial applications

J Cheng, J Hu - ChemMedChem, 2021 - Wiley Online Library
Carbon monoxide (CO) has been known as an endogenous signaling molecule in addition
to an air pollutant. It plays a critical role in many physiological and pathological processes …

Hydrogen sulfide and carbon monoxide tolerance in bacteria

SS Mendes, V Miranda, LM Saraiva - Antioxidants, 2021 - mdpi.com
Hydrogen sulfide and carbon monoxide share the ability to be beneficial or harmful
molecules depending on the concentrations to which organisms are exposed. Interestingly …

Local delivery of gaseous signaling molecules for orthopedic disease therapy

J Sun, W Wang, X Hu, X Zhang, C Zhu, J Hu… - Journal of …, 2023 - Springer
Over the past decade, a proliferation of research has used nanoparticles to deliver gaseous
signaling molecules for medical purposes. The discovery and revelation of the role of …