The biogenesis, development and metastases of cancer are associated with many variations
in the transcriptome. Alternative splicing of genes is a major post-transcriptional regulation …

Motivation: Genome browsers that support fast navigation through vast datasets and provide
interactive visual analytics functions can help scientists achieve deeper insight into …

Following the successes of monoclonal antibody immunotherapies (trastuzumab
(Herceptin®) and rituximab (Rituxan®)) and the first approved cancer vaccine …

We report that two oncogenes coamplified on chromosome 3q26, PRKCI and SOX2,
cooperate to drive a stem-like phenotype in lung squamous cell carcinoma (LSCC). Protein …

We introduce a novel implementation in ANSI C of the MINE family of algorithms for
computing maximal information-based measures of dependence between two variables in …

The determination of the alternative splicing isoforms expressed in cancer is fundamental for
the development of tumor-specific molecular targets for prognosis and therapy, but it is …

Currently, oncology testing includes molecular studies and cytogenetic analysis to detect
genetic aberrations of clinical significance. Next-generation sequencing (NGS) allows rapid …

We report that the protein kinase Cι (PKCι) oncogene controls expression of NOTCH3, a key
driver of stemness, in KRAS-mediated lung adenocarcinoma (LADC). PKCι activates …

Cancer is an extremely diverse and complex disease that results from various genetic and
epigenetic changes such as DNA copy-number variations, mutations, and aberrant mRNA …

Early screening for colorectal cancer (CRC) holds the key to combat and control the
increasing global burden of CRC morbidity and mortality. However, the current available …