Cyclin D1, an important regulator of cell cycle, carries out a central role in the pathogenesis
of cancer determining uncontrolled cellular proliferation. In normal cells, Cyclin D1 …

Mammalian cells encode three D cyclins (D1, D2, and D3) that coordinately function as
allosteric regulators of cyclin-dependent kinase 4 (CDK4) and CDK6 to regulate cell cycle …

The roles of cyclins and their catalytic partners, the cyclin-dependent kinases (CDKs), as
core components of the machinery that drives cell cycle progression are well established …

The cell cycle is tightly regulated by cyclins and their catalytic moieties, the cyclin-dependent
kinases (CDKs). Cyclin D1, in association with CDK4/6, acts as a mitogenic sensor and …

The mammalian cell cycle is driven by a complex of cyclins and their associated cyclin-
dependent kinases (CDKs). Abnormal dysregulation of cyclin-CDK is a hallmark of cancer. D …

Cancer, a disease of inappropriate cell proliferation, is strongly interconnected with the cell
cycle. All cancers consist of an abnormal accumulation of neoplastic cells, which are …

Purpose The clinical management of patients with castration-resistant prostate cancer
(CRPC) is difficult. However, novel treatment methods are gradually being introduced …

Let-7 miRNAs are involved in carcinogenesis and tumor progression through their roles in
maintaining differentiation and normal development. However, there is little research …

The microRNA family, miR-30, plays diverse roles in regulating key aspects of neoplastic
transformation, metastasis, and clinical outcomes in different types of tumors. Accumulating …

Cancer, a condition characterized by abnormal cell growth, is closely linked to the cell cycle.
In reaction to mitogenic cues, all malignancies comprise an aberrant buildup of tumor …