Antibody-mediated neutralization of SARS-CoV-2

H Gruell, K Vanshylla, T Weber, CO Barnes, C Kreer… - Immunity, 2022 - cell.com
Neutralizing antibodies can block infection, clear pathogens, and are essential to provide
long-term immunity. Since the onset of the pandemic, SARS-CoV-2 neutralizing antibodies …

[HTML][HTML] Wastewater sequencing reveals early cryptic SARS-CoV-2 variant transmission

S Karthikeyan, JI Levy, P De Hoff, G Humphrey… - Nature, 2022 - nature.com
As SARS-CoV-2 continues to spread and evolve, detecting emerging variants early is critical
for public health interventions. Inferring lineage prevalence by clinical testing is infeasible at …

[HTML][HTML] Neutralizing immunity in vaccine breakthrough infections from the SARS-CoV-2 Omicron and Delta variants

V Servellita, AM Syed, MK Morris, N Brazer, P Saldhi… - Cell, 2022 - cell.com
Virus-like particle (VLP) and live virus assays were used to investigate neutralizing immunity
against Delta and Omicron SARS-CoV-2 variants in 259 samples from 128 vaccinated …

[HTML][HTML] SARS-CoV-2 variant Delta rapidly displaced variant Alpha in the United States and led to higher viral loads

A Bolze, S Luo, S White, ET Cirulli, D Wyman… - Cell Reports …, 2022 - cell.com
We report on the sequencing of 74,348 SARS-CoV-2 positive samples collected across the
United States and show that the Delta variant, first detected in the United States in March …

[HTML][HTML] VLP-based COVID-19 vaccines: An adaptable technology against the threat of new variants

WA Prates-Syed, LCS Chaves, KP Crema, L Vuitika… - Vaccines, 2021 - mdpi.com
Virus-like particles (VLPs) are a versatile, safe, and highly immunogenic vaccine platform.
Recently, there are developmental vaccines targeting SARS-CoV-2, the causative agent of …

[HTML][HTML] Data-driven analysis of amino acid change dynamics timely reveals SARS-CoV-2 variant emergence

A Bernasconi, L Mari, R Casagrandi, S Ceri - Scientific Reports, 2021 - nature.com
Since its emergence in late 2019, the diffusion of SARS-CoV-2 is associated with the
evolution of its viral genome. The co-occurrence of specific amino acid changes, collectively …

Unusual SARS-CoV-2 intrahost diversity reveals lineage superinfection

FZ Dezordi, PC Resende, FG Naveca… - Microbial …, 2022 - microbiologyresearch.org
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has infected almost 200
million people worldwide by July 2021 and the pandemic has been characterized by …

Parallel detection of SARS‐CoV‐2 epitopes reveals dynamic immunodominance profiles of CD8+ T memory cells in convalescent COVID‐19 donors

J van den Dijssel, RR Hagen… - Clinical & …, 2022 - Wiley Online Library
Abstract Objectives High‐magnitude CD8+ T cell responses are associated with mild COVID‐
19 disease; however, the underlying characteristics that define CD8+ T cell‐mediated …

[HTML][HTML] CoV2K model, a comprehensive representation of SARS-CoV-2 knowledge and data interplay

T Alfonsi, R Al Khalaf, S Ceri, A Bernasconi - Scientific data, 2022 - nature.com
Since the outbreak of the COVID-19 pandemic, many research organizations have studied
the genome of the SARS-CoV-2 virus; a body of public resources have been published for …

Identification of the first SARS-CoV-2 lineage B. 1.1. 529 virus detected in Europe

B Vanmechelen, AS Logist… - Microbiology …, 2022 - Am Soc Microbiol
We report the complete genome sequence of a severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) Omicron variant (lineage B. 1.1. 529) from a Belgian patient …