Single-cell technologies, particularly single-cell RNA sequencing (scRNA-seq) methods,
together with associated computational tools and the growing availability of public data …

Immunotherapy has revolutionized colon cancer treatment. Immune checkpoint inhibitors
(ICIs) have shown clinical benefits for colon cancer patients, especially those with high …

The efficacy and safety of drugs are widely known to be determined by their interactions with
multiple molecules of pharmacological importance, and it is therefore essential to …

In colorectal cancers, the tumor microenvironment plays a key role in prognosis and therapy
efficacy. Patient-derived tumor organoids (PDTO) show enormous potential for preclinical …

CD8+ T cell activation via immune checkpoint blockade (ICB) is successful in microsatellite
instable (MSI) colorectal cancer (CRC) patients. By comparison, the success of …

Background & Aims As pancreatic ductal adenocarcinoma (PDAC) continues to be
recalcitrant to therapeutic interventions, including poor response to immunotherapy, albeit …

Purpose: The liver is the most frequent metastatic site for colorectal cancer. Its
microenvironment is modified to provide a niche that is conducive for colorectal cancer cell …

Precision medicine has been potentialized with cutting-edge analytical tools based on
electrochemical nanobiosensors as an emerging strategy to personalize diagnosing and …

The consensus molecular subtypes (CMS) of colorectal cancer (CRC) is the most widely-
used gene expression-based classification and has contributed to a better understanding of …

C1q is a crucial component of the complement system, which is activated through the
classical pathway to perform non-specific immune functions, serving as the first line of …