Parkinson's disease (PD) is the second-leading cause of dementia and is characterized by a
progressive loss of dopaminergic neurons in the substantia nigra alongside the presence of …

We have previously proposed that selective inheritance, the limited transmission of
damaging mtDNA mutations from mother to offspring, is based on replication competition in …

We investigated the transport of neuronal mitochondria using superlocalized near-fields with
plasmonic nanohole arrays (PNAs). Compared to traditional imaging techniques, PNAs …

TIMM50, an essential TIM23 complex subunit, is suggested to facilitate the import of~ 60% of
the mitochondrial proteome. In this study, we characterized a TIMM50 disease-causing …

The incidence of major depressive disorder (MDD) is increasing all over the world. There is
a great need for complementary or alternative therapies with high safety, few side effects …

Neurons have intense demands for high energy in order to support their functions. Impaired
mitochondrial transport along axons has been observed in human neurons, which may …

Spinocerebellar ataxia type 3 (SCA3/MJD) is a neurodegenerative disease caused by CAG
expansion in mutant ATXN3 gene. The resulting PolyQ tract in mutant ataxin-3 protein is …

1. Zusammenfassung Bei der Charcot-Marie-Tooth-Neuropathie (CMT, oft synonym
verwendet: Hereditäre motorische und sensible Neuropathie, HMSN) handelt es sich um …

Mitochondria are highly integrated organelles that must readily alter organelle physiology to
adapt to the changing environment of neurons. Failure in the mechanisms regulating …