Progress in the treatment of Ewing's sarcoma, the second most common bone tumour in
children and adolescents, has improved survival from about 10% in the period before …

Increasingly, human mesenchymal malignancies are being classified by the abnormalities
that drive their pathogenesis. Although many of these aberrations are highly prevalent within …

Clinical responses to anticancer therapies are often restricted to a subset of patients. In
some cases, mutated cancer genes are potent biomarkers for responses to targeted agents …

Ewing sarcoma is characterized by the expression of the chimeric EWSR1-FLI1 transcription
factor. Proteomic analyses indicate that the decrease of EWSR1-FLI1 expression leads to …

Research conducted over the past two decades has shown the importance of the type 1
insulin-like growth factor receptor (IGF1R) in tumorigenesis, metastasis, and resistance to …

The cellular origin of Ewing tumor (ET), a tumor of bone or soft tissues characterized by
specific fusions between EWS and ETS genes, is highly debated. Through gene expression …

Transcription factor fusion proteins can transform cells by inducing global changes of the
transcriptome, often creating a state of oncogene addiction. Here, we investigate the role of …

Although some cancers are initially sensitive to EGFR tyrosine kinase inhibitors (TKIs),
resistance invariably develops. We investigated mechanisms of acquired resistance to the …

Cancer can be defined as a genetic disease, resulting as a consequence of multiple events
associated with initiation, promotion and metastatic growth. Cancer results from the loss of …

The IGF system plays critical roles in somatic growth in an endocrine fashion (somatomedin
hypothesis) as well as proliferation and differentiation of normal and malignant cells in a …