Toward low-cost biological and hybrid biological/catalytic conversion of cellulosic biomass to fuels
LR Lynd, GT Beckham, AM Guss… - Energy & …, 2022 - pubs.rsc.org
Developing economically viable, scalable, and sustainable technologies for the conversion
of lignocellulosic polysaccharides to liquid fuels is widely seen as a centerpiece of the …
of lignocellulosic polysaccharides to liquid fuels is widely seen as a centerpiece of the …
Molecular mechanisms of aldehyde toxicity: a chemical perspective
RM LoPachin, T Gavin - Chemical research in toxicology, 2014 - ACS Publications
Aldehydes are electrophilic compounds to which humans are pervasively exposed. Despite
a significant health risk due to exposure, the mechanisms of aldehyde toxicity are poorly …
a significant health risk due to exposure, the mechanisms of aldehyde toxicity are poorly …
Measurement and estimation of electrophilic reactivity for predictive toxicology
JAH Schwöbel, YK Koleva, SJ Enoch, F Bajot… - Chemical …, 2011 - ACS Publications
There is an increasing interest in predicting the toxicological effects of chemicals from their
structure and physicochemical properties. For new compounds, this will optimize the product …
structure and physicochemical properties. For new compounds, this will optimize the product …
The tunable functionality of α, β‐unsaturated carbonyl compounds enables their differential application in biological systems
S Amslinger - ChemMedChem, 2010 - Wiley Online Library
Abstract α, β‐Unsaturated carbonyl compounds as potential drug candidates is a
controversial topic since their potential Michael acceptor activity can lead to cell damage …
controversial topic since their potential Michael acceptor activity can lead to cell damage …
Drug discovery for a new generation of covalent drugs
AS Kalgutkar, DK Dalvie - Expert opinion on drug discovery, 2012 - Taylor & Francis
Introduction: The design of target-specific covalent inhibitors is conceptually attractive
because of increased biochemical efficiency through covalency and increased duration of …
because of increased biochemical efficiency through covalency and increased duration of …
Reactivity of acrylamides causes cytotoxicity and activates oxidative stress response
J Huchthausen, BI Escher, N Grasse… - Chemical research in …, 2023 - ACS Publications
Acrylamides are widely used industrial chemicals that cause adverse effects in humans or
animals, such as carcinogenicity or neurotoxicity. The excess toxicity of these reactive …
animals, such as carcinogenicity or neurotoxicity. The excess toxicity of these reactive …
Prediction of Michael-type acceptor reactivity toward glutathione
JAH Schwöbel, D Wondrousch… - Chemical research in …, 2010 - ACS Publications
A model has been developed to predict the kinetic rate constants (k GSH) of α, β-
unsaturated Michael acceptor compounds for their reaction with glutathione (GSH). The …
unsaturated Michael acceptor compounds for their reaction with glutathione (GSH). The …
Reactive electrophilic oxylipins: pattern recognition and signalling
MJ Mueller, S Berger - Phytochemistry, 2009 - Elsevier
Oxidized lipids in plants comprise a variety of reactive electrophiles that contain an α, β-
unsaturated carbonyl group. While some of these compounds are formed enzymatically …
unsaturated carbonyl group. While some of these compounds are formed enzymatically …
In situ forming hydrogels by tandem thermal gelling and Michael addition reaction between thermosensitive triblock copolymers and thiolated hyaluronan
R Censi, PJ Fieten, P di Martino, WE Hennink… - …, 2010 - ACS Publications
This study reports on the synthesis, characterization and peptide release behavior of an in
situ physically and chemically cross-linking hydrogel.(Meth) acrylate bearing ABA-triblock …
situ physically and chemically cross-linking hydrogel.(Meth) acrylate bearing ABA-triblock …
Biopolymers for tissue engineering: crosslinking, printing techniques, and applications
D Patrocinio, V Galván-Chacón, JC Gómez-Blanco… - Gels, 2023 - mdpi.com
Currently, tissue engineering has been dedicated to the development of 3D structures
through bioprinting techniques that aim to obtain personalized, dynamic, and complex …
through bioprinting techniques that aim to obtain personalized, dynamic, and complex …