Plasma cell neoplasms and related entities—evolution in diagnosis and classification

F Fend, A Dogan, JR Cook - Virchows Archiv, 2023 - Springer
Plasma cell neoplasms including multiple myeloma (MM) and related terminally
differentiated B-cell neoplasms are characterized by secretion of monoclonal …

Advances in the molecular characterization of multiple myeloma and mechanism of therapeutic resistance

M Mejia Saldarriaga, W Darwiche, D Jayabalan… - Frontiers in …, 2022 - frontiersin.org
Recent insight in the genomic landscape of newly diagnosed multiple myeloma (NDMM)
and its precursor conditions, monoclonal gammopathy of uncertain significance (MGUS) …

Plasma cell–derived mtDAMPs activate the macrophage STING pathway, promoting myeloma progression

A Jibril, C Hellmich, EE Wojtowicz… - Blood, The Journal …, 2023 - ashpublications.org
Mitochondrial damage–associated molecular patterns (mtDAMPs) include proteins, lipids,
metabolites, and DNA and have various context-specific immunoregulatory functions. Cell …

Diagnosis and management of smouldering myeloma: a British Society for Haematology Good Practice Paper

D Hughes, K Yong, K Ramasamy, S Stern, E Boyle… - 2024 - Wiley Online Library
Multiple myeloma (MM) is a clonal bone marrow disorder of plasma cells. MM is preceded
by the precursor conditions monoclonal gammopathy of undetermined significance (MGUS) …

Real-world characteristics and outcomes of patients with high-risk and non-high-risk smoldering multiple myeloma using the Flatiron Health database

SV Rajkumar, MV Mateos, M Schaeffer, X Lin… - Blood Cancer …, 2024 - nature.com
This study aimed to provide real-world evidence on progression risk in patients with high-
risk smoldering multiple myeloma (SMM). This retrospective, observational study leveraged …

Comprehensive analysis of prognosis of cuproptosis-related oxidative stress genes in multiple myeloma

T Li, L Yao, Y Hua, Q Wu - Frontiers in Genetics, 2023 - frontiersin.org
Introduction: Multiple myeloma (MM) is a highly heterogeneous hematologic malignancy.
The patients' survival outcomes vary widely. Establishing a more accurate prognostic model …

Gene interaction network analysis in multiple myeloma detects complex immune dysregulation associated with shorter survival

AK Simhal, KH Maclachlan, R Elkin, J Zhu… - Blood Cancer …, 2023 - nature.com
The plasma cell cancer multiple myeloma (MM) varies significantly in genomic
characteristics, response to therapy, and long-term prognosis. To investigate global …

Inference of genomic lesions from single-cell RNA-seq in myeloma improves functional intraclonal and interclonal analysis

F Lazzaroni, A Matera, A Marella, A Maeda… - Blood …, 2024 - ashpublications.org
Smoldering multiple myeloma (SMM) is an asymptomatic plasma cell (PC) neoplasm that
may evolve with variable frequency into multiple myeloma (MM). SMM is initiated by …

Waldenström macroglobulinemia whole genome reveals prolonged germinal center activity and late copy number aberrations

KH Maclachlan, T Bagratuni, E Kastritis… - Blood …, 2023 - ashpublications.org
The genomic landscape of Waldenström macroglobulinemia (WM) is characterized by
somatic mutations in MYD88, present from the precursor stages. Using the comprehensive …

Smoldering multiple myeloma: taking the narrow over the wide path?

H Avet-Loiseau, NJ Bahlis - Blood, 2024 - ashpublications.org
Smoldering multiple myeloma (MM) is an asymptomatic clonal plasma cell condition
considered as a premalignant entity that may evolve over time to symptomatic MM. Based on …