Applications of artificial intelligence and machine learning algorithms to crystallization
Artificial intelligence and specifically machine learning applications are nowadays used in a
variety of scientific applications and cutting-edge technologies, where they have a …
variety of scientific applications and cutting-edge technologies, where they have a …
Crystal nucleation in liquids: Open questions and future challenges in molecular dynamics simulations
The nucleation of crystals in liquids is one of nature's most ubiquitous phenomena, playing
an important role in areas such as climate change and the production of drugs. As the early …
an important role in areas such as climate change and the production of drugs. As the early …
A review on the modernization of pharmaceutical development and manufacturing–Trends, perspectives, and the role of mathematical modeling
Recently, the pharmaceutical industry has been facing several challenges associated to the
use of outdated development and manufacturing technologies. The return on investment on …
use of outdated development and manufacturing technologies. The return on investment on …
Assessment of recent process analytical technology (PAT) trends: a multiauthor review
This multiauthor review article aims to bring readers up to date with some of the current
trends in the field of process analytical technology (PAT) by summarizing each aspect of the …
trends in the field of process analytical technology (PAT) by summarizing each aspect of the …
Advances and new directions in crystallization control
The academic literature on and industrial practice of control of solution crystallization
processes have seen major advances in the past 15 years that have been enabled by …
processes have seen major advances in the past 15 years that have been enabled by …
First-principles and direct design approaches for the control of pharmaceutical crystallization
Crystallization is the main separation and purification process for the manufacturing of drug
substances. Not only does crystallization affect the efficiency of downstream operations such …
substances. Not only does crystallization affect the efficiency of downstream operations such …
Applications of process analytical technology to crystallization processes
XY Lawrence, RA Lionberger, AS Raw… - Advanced drug delivery …, 2004 - Elsevier
Crystallizations of pharmaceutical active ingredients, particularly those that posses multiple
polymorphic forms, are among the most critical and least understood pharmaceutical …
polymorphic forms, are among the most critical and least understood pharmaceutical …
Overview of secondary nucleation: From fundamentals to application
S Xu, Z Hou, X Chuai, Y Wang - Industrial & Engineering …, 2020 - ACS Publications
Secondary nucleation can bring the crystallization process into a more easily controlled
state, and it is playing an important role in controlling crystal size distribution, polymorphism …
state, and it is playing an important role in controlling crystal size distribution, polymorphism …
The impact of direct nucleation control on crystal size distribution in pharmaceutical crystallization processes
The control of crystal size distribution (CSD) in pharmaceutical crystallization is of primary
importance, as downstream processes such as filtration or drying are greatly affected by the …
importance, as downstream processes such as filtration or drying are greatly affected by the …
Advanced control of crystallization processes
RD Braatz - Annual reviews in control, 2002 - Elsevier
A key bottleneck in the production of pharmaceuticals and many other products is the
formation of crystals from solution. The control of the crystal size distribution can be critically …
formation of crystals from solution. The control of the crystal size distribution can be critically …