Abstract The 2, 5-diketopiperazines are a prominent class of bioactive molecules. The
nocardioazines are actinomycete natural products that feature a pyrroloindoline …

Cyclodipeptides from fungi and bacteria are often modified by different tailoring enzymes.
They display various biological and pharmacological activities, and some derivatives are …

We report a novel approach to access spirocyclic compounds containing a diketopiperazine
(DKP) motif fused on a pyrrolidine ring. The shared spirocyclic carbon is at the ketone …

Epidithiodioxopiperazine (ETP) alkaloids, featuring a 2, 5‐diketopiperazine core and
transannular disulfide bridge, exhibit a broad spectrum of biological activities. However, the …

环二肽(cyclodipeptide, CDP) 是一类由2 个α-氨基酸缩合而成的最小环肽分子,
也可称为二酮哌嗪类化合物(diketopiperazines, DKPs). CDP 具有稳定的DKP 环状骨架结构 …

Bacterial cytochrome P450 enzymes catalyze various and often intriguing tailoring reactions
during the biosynthesis of natural products. In contrast to the majority of membrane-bound …

Natural products have high structural diversity with various pharmacological or biological
activities, which are of great significance to our life and drug research. Millions of natural …