Decades of research in skeletal muscle physiology have provided multiscale insights into
the structural and functional complexity of this important anatomical tissue, designed to …

Cardiac and skeletal striated muscles are intricately designed machines responsible for
muscle contraction. Coordination of the basic contractile unit, the sarcomere, and the …

Titin is a giant vertebrate striated muscle protein with critical importance for myofibril
elasticity and structural integrity. We show here that the complete sequence of the human …

The sarcomere contains, in addition to thin and thick filaments, a filament composed of the
giant protein titin (also known as connectin). Titin molecules anchor in the Z-disc and extend …

The history of click-speaking Khoe-San, and African populations in general, remains poorly
understood. We genotyped∼ 2.3 million single-nucleotide polymorphisms in 220 southern …

▪ Abstract Striated muscle is an intricate, efficient, and precise machine that contains
complex interconnected cytoskeletal networks critical for its contractile activity. The …

Anthracycline antibiotics have saved the lives of many cancer victims in the 50 plus years
since their discovery. A major limitation of their use is the dose-limiting cardiotoxicity. Efforts …

Like the ancient Greek hero Hercules, striated muscle is famous for performing impressive
feats of strength. The procurement of food, breathing, and defense or escape from harm all …

Cell biologists have undergone a fundamental revision in their thinking in the past 20 years,
with the realization that cells are far more elegant and efficient than was previously believed …

Myofibrillogenesis in striated muscles is a highly complex process that depends on the
coordinated assembly and integration of a large number of contractile, cytoskeletal, and …