Abstract Purpose of Review Aneurysmal subarachnoid hemorrhage remains a devastating
disease process despite medical advances made over the past 3 decades. Much of the …

Status epilepticus (SE) treatment strategies vary substantially from one institution to another
due to the lack of data to support one treatment over another. To provide guidance for the …

Microglia are the main immune cells of the brain and contribute to common brain diseases.
However, it is unclear how microglia influence neuronal activity and survival in the injured …

Methods: The Critical Care Continuous EEG Task Force of the American Clinical
Neurophysiology Society developed expert consensus recommendations on the use of …

A modern understanding of how cerebral cortical lesions develop after acute brain injury is
based on Aristides Leão's historic discoveries of spreading depression and asphyxial/anoxic …

Mapping the entire frequency bandwidth of brain electrophysiological signals is of
paramount importance for understanding physiological and pathological states. The ability …

Traumatic brain injury (TBI) is a significant clinical problem with few therapeutic interventions
successfully translated to the clinic. Increased importance on the progressive, long-term …

Spreading depolarizations (SD) are waves of abrupt, near-complete breakdown of neuronal
transmembrane ion gradients, are the largest possible pathophysiologic disruption of viable …

The term spreading depolarization (SD) refers to waves of abrupt, sustained mass
depolarization in gray matter of the CNS. SD, which spreads from neuron to neuron in …

Spreading depolarization (SD) is a phenomenon of various cerebral gray matter structures
that only occurs under pathological conditions. In the present paper, we summarize the …