Nitric oxide is a versatile molecule, with its actions ranging from haemodynamic regulation to
anti‐proliferative effects on vascular smooth muscle cells. Nitric oxide is produced by the …

Background: Inadequate nitric oxide (NO) availability may underlie vascular smooth muscle
overgrowth that contributes to vascular occlusive diseases including atherosclerosis and …

In cardiac transplantation, chronic rejection takes the form of an occlusive vasculopathy. The
mechanism underlying this disorder remains unclear. The purpose of this study was to …

Mutations in filamin B (FLNB), a gene encoding a cytoplasmic actin-binding protein, have
been found in human skeletal disorders, including boomerang dysplasia …

NO prevents atherogenesis and inflammation in vessel walls by inhibition of cell proliferation
and cytokine-induced endothelial expression of adhesion molecules and proinflammatory …

A novel insulin sensitizing agent, thiazolidine, has been demonstrated to inhibit the growth
of cultured vascular smooth muscle cells (VSMC) in vitro. This study was undertaken to …

Accumulating evidence supports an autoimmune mechanism as one of the prime
pathogenic processes involved in the development of atherosclerosis. So far, three proteins …

Background—Inducible NO synthase (NOS2, or iNOS) is upregulated in grafts with
transplant arteriosclerosis. However, the functional role of NOS2 in the pathogenesis of …

Within vessels, the formation of nitric oxide (NO) or prostaglandins is normally catalysed in
the endothelium by constitutive isoforms of NO synthase (eNOS) and cyclo‐oxygenase …

Previous animal studies have shown that angiotensin (Ang)-(1-7) is a biologically active
component of the renin-angiotensin system, acting as a vasoactive agent, and may play a …