Beyond sexual functions, androgens exert their action in skin physiology and
pathophysiology. Skin cells are able to synthesize most active androgens from gonadal or …

Abstract A nanocomposite microneedle (ZCQ/MN) patch containing copper/zinc dual-doped
mesoporous silica nanoparticles loaded with quercetin (ZCQ) was developed as a …

The Wnt/β-catenin pathway has been implicated in hair follicle development and hair
regeneration in adults. We discovered that CXXC-type zinc finger protein 5 (CXXC5) is a …

Compared to a plasmid, viral, and other delivery systems, direct Cas9/sgRNA protein
delivery has several advantages such as low off-targeting effects and non-integration, but it …

Background Androgenetic alopecia (AGA) is a genetic disorder caused by
dihydrotestosterone (DHT), accompanied by the senescence of androgen-sensitive dermal …

Androgenic alopecia, also known as pattern hair loss, is a chronic progressive condition that
affects 80% of men and 50% of women throughout a lifetime. But despite its prevalence and …

Abstract Background Dermal papilla cells (DPCs) play a key role in hair growth among the
various cell types in hair follicles. Especially, DPCs determine the fate of hair follicle such as …

Autocrine and paracrine factors play key roles in the process of Androgenetic alopecia
(AGA), which are secreted by balding dermal papilla cells (DPCs) after dihydrotestosterone …

Background Hair follicle is miniorgan constituted by keratinocytes and its distinctive
mesenchyme of dermal papilla. Its aging is characterized by organ atrophy and impaired …

Oxidative stress and cellular senescence in dermal papilla cells (DPCs) are major
etiological factors causing hair loss. In this study, the effect of the Allium hookeri extract …