Dietary restriction with adequate nutrition is the gold standard for delaying ageing and
extending healthspan and lifespan in diverse species, including rodents and non-human …

An epidemic of obesity has affected large portions of the world, increasing the risk of
developing many different age-associated diseases, including cancer, cardiovascular …

Methionine uptake and metabolism is involved in a host of cellular functions including
methylation reactions, redox maintenance, polyamine synthesis and coupling to folate …

The mammalian/mechanistic target of rapamycin (mTOR) is a key component of cellular
metabolism that integrates nutrient sensing with cellular processes that fuel cell growth and …

BACKGROUND Reduced caloric intake without malnutrition is the oldest known life span–
extending intervention. Laboratory studies throughout the 20th century established and …

Fibroblast growth factor 21 (FGF21) is a peptide hormone that is synthesized by several
organs and regulates energy homeostasis. Excitement surrounding this relatively recently …

Key points We recently found that feeding healthy mice a diet with reduced levels of
branched-chain amino acids (BCAAs), which are associated with insulin resistance in both …

Summary Protein-restricted (PR), high-carbohydrate diets improve metabolic health in
rodents, yet the precise dietary components that are responsible for these effects have not …

Methionine restriction (MetR) extends lifespan across different species and exerts beneficial
effects on metabolic health and inflammatory responses. In contrast, certain cancer cells …

The protein kinase mechanistic target of rapamycin (mTOR) functions as a central regulator
of metabolism, integrating diverse nutritional and hormonal cues to control anabolic …