The regulators of G-protein signaling (RGS) proteins were initially characterized as inhibitors
of signal transduction cascades initiated by G-protein-coupled receptors (GPCR) because of …

Cell migration is a fundamental biological process involved in normal physiology. Altered
motile phenotypes are however often associated with the development and progression of …

The origin of tumor-infiltrating Tregs, critical mediators of tumor immunosuppression, is
unclear. Here, we show that tumor-infiltrating naive CD4+ T cells and Tregs in human breast …

Reduced infiltration of anti-tumor lymphocytes remains a major cause of tumor immune
evasion and is correlated with poor cancer survival. Here, we found that upregulation of …

Nonlinear data visualization methods, such as t-distributed stochastic neighbor embedding
(t-SNE) and uniform manifold approximation and projection (UMAP), summarize the …

To determine whether gene expression profiling could improve outcome prediction in
children with acute lymphoblastic leukemia (ALL) at high risk for relapse, we profiled …

Background Effective treatment is needed for advanced, inoperable, or chemotherapy-
resistant cervical cancer patients. Immunotherapy has become a new treatment modality for …

Compelling evidence suggests that diverse types of immune reactions can be suppressed
by CD25+ CD4+ regulatory T cells (Tregs). Although increasing knowledge has …

Background CD4+ T cells are key regulators of the adaptive immune system and can be
divided into T helper (Th) cells and regulatory T (Treg) cells. During an immune response Th …

G protein-coupled receptors (GPCRs) have important functions in both innate and adaptive
immunity, with the capacity to bridge interactions between the two arms of the host …