Astrocytes in the initiation and progression of epilepsy
Epilepsy affects~ 65 million people worldwide. First-line treatment options include> 20
antiseizure medications, but seizure control is not achieved in approximately one-third of …
antiseizure medications, but seizure control is not achieved in approximately one-third of …
Neuron–glia interactions in the pathophysiology of epilepsy
Epilepsy is a neurological disorder afflicting~ 65 million people worldwide. It is caused by
aberrant synchronized firing of populations of neurons primarily due to imbalance between …
aberrant synchronized firing of populations of neurons primarily due to imbalance between …
The perineuronal 'safety'net? Perineuronal net abnormalities in neurological disorders
Perineuronal nets (PNN) are extracellular matrix (ECM) assemblies that preferentially
ensheath parvalbumin (PV) expressing interneurons. Converging evidence indicates that …
ensheath parvalbumin (PV) expressing interneurons. Converging evidence indicates that …
A delicate balance: role of MMP-9 in brain development and pathophysiology of neurodevelopmental disorders
The extracellular matrix (ECM) is a critical regulator of neural network development and
plasticity. As neuronal circuits develop, the ECM stabilizes synaptic contacts, while its …
plasticity. As neuronal circuits develop, the ECM stabilizes synaptic contacts, while its …
Neuroinflammatory targets and treatments for epilepsy validated in experimental models
A large body of evidence that has accumulated over the past decade strongly supports the
role of inflammation in the pathophysiology of human epilepsy. Specific inflammatory …
role of inflammation in the pathophysiology of human epilepsy. Specific inflammatory …
Formation and remodeling of the brain extracellular matrix in neural plasticity: Roles of chondroitin sulfate and hyaluronan
S Miyata, H Kitagawa - Biochimica et Biophysica Acta (BBA)-General …, 2017 - Elsevier
Background The extracellular matrix (ECM) of the brain is rich in glycosaminoglycans such
as chondroitin sulfate (CS) and hyaluronan. These glycosaminoglycans are organized into …
as chondroitin sulfate (CS) and hyaluronan. These glycosaminoglycans are organized into …
Perineuronal nets in brain physiology and disease
D Testa, A Prochiantz, AA Di Nardo - Seminars in cell & developmental …, 2019 - Elsevier
Perineuronal nets (PNNs) in the brain are condensed glycosaminoglycan-rich extracellular
matrix structures with heterogeneous composition yet specific organization. They typically …
matrix structures with heterogeneous composition yet specific organization. They typically …
Perineuronal nets in the adult sensory cortex are necessary for fear learning
SB Banerjee, VA Gutzeit, J Baman, HS Aoued… - Neuron, 2017 - cell.com
Lattice-like structures known as perineuronal nets (PNNs) are key components of the
extracellular matrix (ECM). Once fully crystallized by adulthood, they are largely stable …
extracellular matrix (ECM). Once fully crystallized by adulthood, they are largely stable …
MMP9/RAGE pathway overactivation mediates redox dysregulation and neuroinflammation, leading to inhibitory/excitatory imbalance: a reverse translation study in …
D Dwir, B Giangreco, L Xin, L Tenenbaum… - Molecular …, 2020 - nature.com
Various mechanisms involved in schizophrenia pathophysiology, such as dopamine
dysregulation, glutamate/NMDA receptor dysfunction, neuroinflammation or redox …
dysregulation, glutamate/NMDA receptor dysfunction, neuroinflammation or redox …
Perineuronal nets decrease membrane capacitance of peritumoral fast spiking interneurons in a model of epilepsy
Brain tumor patients commonly present with epileptic seizures. We show that tumor-
associated seizures are the consequence of impaired GABAergic inhibition due to an overall …
associated seizures are the consequence of impaired GABAergic inhibition due to an overall …