Human diseases, particularly infectious diseases and cancers, pose unprecedented
challenges to public health security and the global economy. The development and …

Marburg virus (MARV) has been a major concern since 1967, with two major outbreaks
occurring in 1998 and 2004. Infection from MARV results in severe hemorrhagic fever …

Background rVSV-ZEBOV is a recombinant, replication competent vesicular stomatitis virus-
based candidate vaccine expressing a surface glycoprotein of Zaire Ebolavirus. We tested …

Filoviruses are emerging pathogens and causative agents of viral haemorrhagic fever. Case
fatality rates of filovirus disease outbreaks are among the highest reported for any human …

Background The worst Ebola virus disease (EVD) outbreak in history has resulted in more
than 28,000 cases and 11,000 deaths. We present the final results of two phase 1 trials of an …

Ebola viruses are the causative agents of a severe form of viral haemorrhagic fever in man,
designated Ebola haemorrhagic fever, and are endemic in regions of central Africa. The …

Highlights•Unpredictable Ebola epidemics hamper determination of vaccine
efficacy.•Ervebo and Zabdeno/Mvabea vaccines receive approval for use.•Approved Ebola …

In 1967, the first reported filovirus hemorrhagic fever outbreak took place in Germany and
the former Yugoslavia. The causative agent that was identified during this outbreak, Marburg …

Objectives This article summarizes the countermeasures for Marburg virus disease, focusing
on pathogenesis, clinical features and diagnostics. There is an emphasis on therapies and …

Ebola viruses (EBOV) cause often fatal hemorrhagic fever in several species of simian
primates including human. While fruit bats are considered natural reservoir, involvement of …