Viral vectored vaccines: design, development, preventive and therapeutic applications in human diseases
S Wang, B Liang, W Wang, L Li, N Feng… - Signal transduction and …, 2023 - nature.com
Human diseases, particularly infectious diseases and cancers, pose unprecedented
challenges to public health security and the global economy. The development and …
challenges to public health security and the global economy. The development and …
Pathogenicity and virulence of Marburg virus
Marburg virus (MARV) has been a major concern since 1967, with two major outbreaks
occurring in 1998 and 2004. Infection from MARV results in severe hemorrhagic fever …
occurring in 1998 and 2004. Infection from MARV results in severe hemorrhagic fever …
[HTML][HTML] Efficacy and effectiveness of an rVSV-vectored vaccine in preventing Ebola virus disease: final results from the Guinea ring vaccination, open-label, cluster …
Background rVSV-ZEBOV is a recombinant, replication competent vesicular stomatitis virus-
based candidate vaccine expressing a surface glycoprotein of Zaire Ebolavirus. We tested …
based candidate vaccine expressing a surface glycoprotein of Zaire Ebolavirus. We tested …
Protection against filovirus diseases by a novel broad-spectrum nucleoside analogue BCX4430
TK Warren, J Wells, RG Panchal, KS Stuthman… - Nature, 2014 - nature.com
Filoviruses are emerging pathogens and causative agents of viral haemorrhagic fever. Case
fatality rates of filovirus disease outbreaks are among the highest reported for any human …
fatality rates of filovirus disease outbreaks are among the highest reported for any human …
A recombinant vesicular stomatitis virus Ebola vaccine
JA Regules, JH Beigel, KM Paolino… - … England Journal of …, 2017 - Mass Medical Soc
Background The worst Ebola virus disease (EVD) outbreak in history has resulted in more
than 28,000 cases and 11,000 deaths. We present the final results of two phase 1 trials of an …
than 28,000 cases and 11,000 deaths. We present the final results of two phase 1 trials of an …
Ebola haemorrhagic fever
H Feldmann, TW Geisbert - The Lancet, 2011 - thelancet.com
Ebola viruses are the causative agents of a severe form of viral haemorrhagic fever in man,
designated Ebola haemorrhagic fever, and are endemic in regions of central Africa. The …
designated Ebola haemorrhagic fever, and are endemic in regions of central Africa. The …
Ebola virus disease: current vaccine solutions
O Tomori, MO Kolawole - Current Opinion in Immunology, 2021 - Elsevier
Highlights•Unpredictable Ebola epidemics hamper determination of vaccine
efficacy.•Ervebo and Zabdeno/Mvabea vaccines receive approval for use.•Approved Ebola …
efficacy.•Ervebo and Zabdeno/Mvabea vaccines receive approval for use.•Approved Ebola …
Forty-five years of Marburg virus research
In 1967, the first reported filovirus hemorrhagic fever outbreak took place in Germany and
the former Yugoslavia. The causative agent that was identified during this outbreak, Marburg …
the former Yugoslavia. The causative agent that was identified during this outbreak, Marburg …
[HTML][HTML] Marburg virus disease: a summary for clinicians
MG Kortepeter, K Dierberg, ES Shenoy… - International Journal of …, 2020 - Elsevier
Objectives This article summarizes the countermeasures for Marburg virus disease, focusing
on pathogenesis, clinical features and diagnostics. There is an emphasis on therapies and …
on pathogenesis, clinical features and diagnostics. There is an emphasis on therapies and …
Transmission of Ebola virus from pigs to non-human primates
HM Weingartl, C Embury-Hyatt, C Nfon, A Leung… - Scientific reports, 2012 - nature.com
Ebola viruses (EBOV) cause often fatal hemorrhagic fever in several species of simian
primates including human. While fruit bats are considered natural reservoir, involvement of …
primates including human. While fruit bats are considered natural reservoir, involvement of …