[HTML][HTML] Lipid metabolism in sickness and in health: Emerging regulators of lipotoxicity

H Yoon, JL Shaw, MC Haigis, A Greka - Molecular cell, 2021 - cell.com
Lipids play crucial roles in signal transduction, contribute to the structural integrity of cellular
membranes, and regulate energy metabolism. Questions remain as to which lipid species …

Obesity cardiomyopathy: evidence, mechanisms, and therapeutic implications

J Ren, NN Wu, S Wang, JR Sowers… - Physiological …, 2021 - journals.physiology.org
The prevalence of heart failure is on the rise and imposes a major health threat, in part, due
to the rapidly increased prevalence of overweight and obesity. To this point …

[HTML][HTML] Cardiac transmembrane ion channels and action potentials: cellular physiology and arrhythmogenic behavior

V András, J Tomek, N Nagy, L Virág… - Physiological …, 2021 - journals.physiology.org
Cardiac arrhythmias are among the leading causes of mortality. They often arise from
alterations in the electrophysiological properties of cardiac cells and their underlying ionic …

[HTML][HTML] Effect of medium chain fatty acid in human health and disease

PG Roopashree, SS Shetty, NS Kumari - Journal of Functional Foods, 2021 - Elsevier
Medium chain fatty acids (MCFAs) has unique transport system and is rapidly metabolized in
the body. It mainly occurs in coconut oil, palm kernel oil and milk products. Dietary …

Molecular and cellular mechanisms of cardiovascular disorders in diabetes

MS Shah, M Brownlee - Circulation research, 2016 - Am Heart Assoc
The clinical correlations linking diabetes mellitus with accelerated atherosclerosis,
cardiomyopathy, and increased post-myocardial infarction fatality rates are increasingly …

Diabetic cardiomyopathy: mechanisms and new treatment strategies targeting antioxidant signaling pathways

K Huynh, BC Bernardo, JR McMullen… - Pharmacology & …, 2014 - Elsevier
Cardiovascular disease is the primary cause of morbidity and mortality among the diabetic
population. Both experimental and clinical evidence suggest that diabetic subjects are …

Myocardial fatty acid metabolism in health and disease

GD Lopaschuk, JR Ussher, CDL Folmes… - Physiological …, 2010 - journals.physiology.org
There is a constant high demand for energy to sustain the continuous contractile activity of
the heart, which is met primarily by the β-oxidation of long-chain fatty acids. The control of …

Lipid use and misuse by the heart

PC Schulze, K Drosatos, IJ Goldberg - Circulation research, 2016 - Am Heart Assoc
The heart utilizes large amounts of fatty acids as energy providing substrates. The
physiological balance of lipid uptake and oxidation prevents accumulation of excess lipids …

The human microcirculation: regulation of flow and beyond

DD Gutterman, DS Chabowski, AO Kadlec… - Circulation …, 2016 - Am Heart Assoc
The microcirculation is responsible for orchestrating adjustments in vascular tone to match
local tissue perfusion with oxygen demand. Beyond this metabolic dilation, the …

Molecular distinction between physiological and pathological cardiac hypertrophy: experimental findings and therapeutic strategies

BC Bernardo, KL Weeks, L Pretorius… - Pharmacology & …, 2010 - Elsevier
Cardiac hypertrophy can be defined as an increase in heart mass. Pathological cardiac
hypertrophy (heart growth that occurs in settings of disease, eg hypertension) is a key risk …