In an increasing number of states and countries, cannabis now stands poised to join alcohol
and tobacco as a legal drug. Quantifying the relative adverse and beneficial effects of …

Cannabis sativa is the source of a unique set of compounds known collectively as plant
cannabinoids or phytocannabinoids. This review focuses on the manner with which three of …

Background The past two decades have seen an increase in cannabis use due to both
regulatory changes and an interest in potential therapeutic effects of the substance, yet …

ABSTRACT A major finding—that (–)‐trans‐Δ9‐tetrahydrocannabinol (Δ9‐THC) is largely
responsible for the psychotropic effects of cannabis—prompted research in the 1970s and …

Cannabinoids impair hippocampus-dependent memory in both humans and animals, but
the network mechanisms responsible for this effect are unknown. Here we show that the …

Since the discovery of the endocannabinoid system, a growing body of psychiatric research
has emerged focusing on the role of this system in major psychiatric disorders like …

This paper is the 29th consecutive installment of the annual review of research concerning
the endogenous opioid system, now spanning 30 years of research. It summarizes papers …

Medical cannabis (MC) describes the usually inhaled or ingested use of a cannabis plant or
cannabis extract for medicinal purposes. The action of whole cannabis plants is extremely …

Addiction is a chronic, recurring and complex disorder. It is characterized by anomalous
behaviors that are linked to permanent or long‐lasting neurobiological alterations …

Background: In recent years, growing concerns about the effects of cannabis use on mental
health have renewed interest in cannabis research. In particular, there has been a marked …