[HTML][HTML] Therapeutic perspective of vitamin C and its derivatives
l-Ascorbic acid (ASA), vitamin C, is a ubiquitous carbohydrate-like compound that has an
essential role in a number of cellular processes, such as collagen synthesis, cellular …
essential role in a number of cellular processes, such as collagen synthesis, cellular …
[HTML][HTML] Understanding the therapeutic potential of ascorbic acid in the battle to overcome cancer
Cancer, a fatal disease, is also one of the main causes of death worldwide. Despite various
developments to prevent and treat cancer, the side effects of anticancer drugs remain a …
developments to prevent and treat cancer, the side effects of anticancer drugs remain a …
Coumarin: a promising scaffold for anticancer agents
M Kaur, S Kohli, S Sandhu, Y Bansal… - Anti-Cancer Agents in …, 2015 - ingentaconnect.com
Coumarin enjoys an important place in drug discovery process due to its presence in
diversity of biologically active compounds. Many compounds of plant origin are derivatives …
diversity of biologically active compounds. Many compounds of plant origin are derivatives …
Novel pyrimidine-2, 4-dione–1, 2, 3-triazole and furo [2, 3-d] pyrimidine-2-one–1, 2, 3-triazole hybrids as potential anti-cancer agents: synthesis, computational and X …
Abstract Regioselective 1, 4-disubstituted 1, 2, 3-triazole tethered pyrimidine-2, 4-dione
derivatives (5–23) were successfully prepared by the copper (I)-catalyzed click chemistry …
derivatives (5–23) were successfully prepared by the copper (I)-catalyzed click chemistry …
Novel 1, 2, 4-triazole and imidazole derivatives of L-ascorbic and imino-ascorbic acid: Synthesis, anti-HCV and antitumor activity evaluations
K Wittine, MS Babić, D Makuc, J Plavec… - Bioorganic & medicinal …, 2012 - Elsevier
Several novel 1, 2, 4-triazole and imidazole l-ascorbic acid (1, 2, 3, 5, 6 and 9) and imino-
ascorbic acid (4, 7 and 8) derivatives were prepared and evaluated for their inhibitory activity …
ascorbic acid (4, 7 and 8) derivatives were prepared and evaluated for their inhibitory activity …
Antitumor and antiviral activities of 4-substituted 1, 2, 3-triazolyl-2, 3-dibenzyl-L-ascorbic acid derivatives
Abstract Two series of 6-(1, 2, 3-triazolyl)-2, 3-dibenzyl-l-ascorbic acid derivatives with the
hydroxyethylene (8a− 8u) and ethylidene linkers (10c− 10p) were synthesized and …
hydroxyethylene (8a− 8u) and ethylidene linkers (10c− 10p) were synthesized and …
Design, synthesis and biological evaluation of novel L-ascorbic acid-conjugated pentacyclic triterpene derivatives as potential influenza virus entry inhibitors
H Wang, R Xu, Y Shi, L Si, P Jiao, Z Fan, X Han… - European journal of …, 2016 - Elsevier
Since the influenza viruses can rapidly evolve, it is urgently required to develop novel anti-
influenza agents possessing a novel mechanism of action. In our previous study, two …
influenza agents possessing a novel mechanism of action. In our previous study, two …
Microwave assisted synthesis of dihydrobenzo [4, 5] imidazo [1, 2-a] pyrimidin-4-ones; synthesis, in vitro antimicrobial and anticancer activities of novel coumarin …
The present article describes the synthesis of dihydrobenzo [4, 5] imidazo [1, 2-a] pyrimidin-
4-one (2a–h) under microwave irradiation. The product was obtained in excellent yield (74 …
4-one (2a–h) under microwave irradiation. The product was obtained in excellent yield (74 …
L-Ascorbic acid in organic synthesis: an overview
RP Tripathi, B Singh, SS Bisht… - Current Organic …, 2009 - ingentaconnect.com
L-Ascorbic acid, commonly known as vitamin C is well-known in chemistry since long back. It
has tremendous medical applications in several diseases. However, application of this chiral …
has tremendous medical applications in several diseases. However, application of this chiral …
Synthesis, cytostatic and anti-HIV evaluations of the new unsaturated acyclic C-5 pyrimidine nucleoside analogues
T Gazivoda, S Raić-Malić, V Krištafor, D Makuc… - Bioorganic & medicinal …, 2008 - Elsevier
A series of the novel C-5 alkynyl pyrimidine nucleoside analogues (1–14) in which the sugar
moiety was replaced by the conformationally restricted Z-and E-2-butenyl spacer between …
moiety was replaced by the conformationally restricted Z-and E-2-butenyl spacer between …