Maintenance of endothelial cell integrity is an important component of human health and
disease since the endothelium can perform various functions including regulation of …

Inflammasomes are a class of cytosolic protein complexes. They act as cytosolic innate
immune signal receptors to sense pathogens and initiate inflammatory responses under …

Recent reports have shown a strong association between obesity and the severity of COVID-
19 infection, even in the absence of other comorbidities. After infecting the host cells, severe …

SARS-CoV-2 might directly activate NLRP3 inflammasome resulting in an endogenous
adjuvant activity necessary to mount a proper adaptive immune response against the virus …

Heightened inflammatory response is a prominent feature of severe COVID-19 disease. We
report that the SARS-CoV-2 ORF3a viroporin activates the NLRP3 inflammasome, the most …

The objective of this comprehensive review is to summarize and discuss the available
evidence of how adipose tissue inflammation affects insulin sensitivity and glucose …

The cause of insulin resistance in obesity and type 2 diabetes mellitus (T2DM) is not limited
to impaired insulin signalling but also involves the complex interplay of multiple metabolic …

The gut microbiota has been linked to the development of obesity and type 2 diabetes (T2D).
The underlying mechanisms as to how intestinal microbiota may contribute to T2D are only …

Hypertension is regarded as the most prominent risk factor for cardiovascular diseases,
which have become a primary cause of death, and recent research has demonstrated that …

The gut microbiota (GM) is defined as the community of microorganisms (bacteria, archaea,
fungi, viruses) colonizing the gastrointestinal tract. GM regulates various metabolic pathways …