Glioblastoma (GBM) is the most common primary malignant brain tumor in adults and has an
exceedingly low median overall survival of only 15 months. Current standard-of-care for …

The relationships between inflammation and cancer are varied and complex. An important
connection linking inflammation to cancer development is DNA damage. During …

Aging in mammals is accompanied by a progressive atrophy of tissues and organs, and
stochastic damage accumulation to the macromolecules DNA, RNA, proteins, and lipids …

Despite advances in neurosurgical techniques and radio-/chemotherapy, the treatment of
brain tumors remains a challenge. This is particularly true for the most frequent and fatal …

Glioblastoma multiforme is the most common aggressive adult primary tumour of the central
nervous system. Treatment includes surgery, radiotherapy and adjuvant temozolomide …

The alkylating agent temozolomide (TMZ) together with maximal safe bulk resection and
focal radiotherapy comprises the standard treatment for glioblastoma (GB), a particularly …

DNA methylation regulates many cellular processes, including embryonic development,
transcription, chromatin structure, X-chromosome inactivation, genomic imprinting and …

Resistance to alkylating agents via direct DNA repair by O6-methylguanine
methyltransferase (MGMT) remains a significant barrier to the successful treatment of …

Glioblastoma is the most aggressive primary brain tumor with a poor prognosis. The 2021
WHO CNS5 classification has further stressed the importance of molecular signatures in …

Base excision repair (BER) is an evolutionarily conserved pathway, which could be
considered the “workhorse” repair mechanism of the cell. In particular, BER corrects most …