Non-canonical WNT signalling in cardiovascular disease: mechanisms and therapeutic implications

I Akoumianakis, M Polkinghorne… - Nature Reviews …, 2022 - nature.com
WNT signalling comprises a diverse spectrum of receptor-mediated pathways activated by a
large family of WNT ligands and influencing fundamental biological processes. WNT …

Biomarkers of oxidative stress in metabolic syndrome and associated diseases

R Vona, L Gambardella, C Cittadini… - Oxidative medicine …, 2019 - Wiley Online Library
Metabolic syndrome (MS) represents worldwide public health issue characterized by a set of
cardiovascular risk factors including obesity, diabetes, dyslipidemia, hypertension, and …

Dyslipidemia, diabetes and atherosclerosis: role of inflammation and ROS-redox-sensitive factors

E Hasheminasabgorji, JC Jha - Biomedicines, 2021 - mdpi.com
The prevalence of diabetes is growing at an alarming rate with increased disability,
morbidity, and often premature mortality because of the various complications of this …

A versatile strategy to construct free-standing multi-furcated vessels and a complicated vascular network in heterogeneous porous scaffolds via combination of 3D …

H Su, Q Li, D Li, H Li, Q Feng, X Cao, H Dong - Materials Horizons, 2022 - pubs.rsc.org
Mimicking complex structures of natural blood vessels and constructing vascular networks in
tissue engineering scaffolds are still challenging now. Herein we demonstrate a new and …

Adipokines from white adipose tissue in regulation of whole body energy homeostasis

B Sahu, NC Bal - Biochimie, 2023 - Elsevier
Diseases originating from altered energy homeostasis including obesity, and type 2
diabetes are rapidly increasing worldwide. Research in the last few decades on animal …

Glutathione stimulates vitamin D regulatory and glucose-metabolism genes, lowers oxidative stress and inflammation, and increases 25-hydroxy-vitamin D levels in …

SK Jain, R Parsanathan, AE Achari… - Antioxidants & redox …, 2018 - liebertpub.com
Abstract Aims: 25-Hydroxyvitamin D [25 (OH) VD] deficiency/inadequacy is a major public
health issue affecting more than 1 billion people worldwide. A convincing association exists …

Chronic SIRT1 supplementation in diabetic mice improves endothelial function by suppressing oxidative stress

K Yang, S Velagapudi, A Akhmedov… - Cardiovascular …, 2023 - academic.oup.com
Aims Enhancing SIRT1 activity exerts beneficial cardiovascular effects. In diabetes, plasma
SIRT1 levels are reduced. We aimed to investigate the therapeutic potential of chronic …

The impact of Vitamin D and L-Cysteine co-supplementation on upregulating glutathione and Vitamin D-metabolizing genes and in the treatment of circulating 25 …

SK Jain, J Justin Margret, SA Abrams, SN Levine… - Nutrients, 2024 - mdpi.com
Vitamin D receptors are expressed in many organs and tissues, which suggests that vitamin
D (VD) affects physiological functions beyond its role in maintaining bone health. Deficiency …

Metabolic syndrome and male fertility: beyond heart consequences of a complex cardiometabolic endocrinopathy

G Salvio, A Ciarloni, M Cutini, N Delli Muti… - International Journal of …, 2022 - mdpi.com
Metabolic syndrome (MetS) is a highly prevalent condition among adult males, affecting up
to 41% of men in Europe. It is characterized by the association of obesity, hypertension, and …

Prevalence, associated factors and psychological determinants of obesity among adults in Selangor, Malaysia

S Mohd-Sidik, R Lekhraj, CN Foo - International journal of environmental …, 2021 - mdpi.com
Background: The pervasiveness of obesity is a growing concern in the world. This study
aims to determine the prevalence of obesity among a segment of the Malaysian population …