Oxygen deprivation (hypoxia) in non–small cell lung cancer (NSCLC) is an important factor
in treatment resistance and poor survival. Hypoxia is an attractive therapeutic target …

While the development of positron emission tomography (PET) radiopharmaceuticals
closely follows that of traditional drug development, there are several key considerations in …

Quantitative radiomics features, extracted from medical images, characterize tumour-
phenotypes and have been shown to provide prognostic value in predicting clinical …

The hypoxic state in a solid tumor refers to the internal hypoxic environment that appears as
the tumor volume increases (the maximum radius exceeds 180-200 microns). This state can …

See an invited perspective on this article on page 1043. This multicenter phase II study
investigated a selective radiotherapy dose increase to tumor areas with significant 18F …

Hypoxia results from an imbalance between oxygen supply and consumption. It is a
common phenomenon in solid malignant tumors such as head and neck cancer. As hypoxic …

Tumor hypoxia is a complex and evolving phenomenon both in time and space. Molecular
imaging allows to approach these variations, but the tracers used have their own limitations …

Purpose Multiple imaging techniques are nowadays available for clinical in-vivo
visualization of tumour biology. FDG PET/CT identifies increased tumour metabolism …

Hypoxia—a common feature of the majority of solid tumors—is a negative prognostic factor,
as it is associated with invasion, metastasis and therapy resistance. To date, a variety of …

Hypoxia is a common feature of solid tumors that is closely associated with radiotherapy and
chemotherapy resistance, metastasis and tumors prognosis. Thus, it is important to assess …