Mathematical modeling of eukaryotic cell migration: insights beyond experiments
A migrating cell is a molecular machine made of tens of thousands of short-lived and
interacting parts. Understanding migration means understanding the self-organization of …
interacting parts. Understanding migration means understanding the self-organization of …
Length control emerges from cytoskeletal network geometry
SG McInally, AJB Reading, A Rosario… - Proceedings of the …, 2024 - pnas.org
Many cytoskeletal networks consist of individual filaments that are organized into elaborate
higher-order structures. While it is appreciated that the size and architecture of these …
higher-order structures. While it is appreciated that the size and architecture of these …
Quantitative regulation of the dynamic steady state of actin networks
Principles of regulation of actin network dimensions are fundamentally important for cell
functions, yet remain unclear. Using both in vitro and in silico approaches, we studied the …
functions, yet remain unclear. Using both in vitro and in silico approaches, we studied the …
A mechanism with severing near barbed ends and annealing explains structure and dynamics of dendritic actin networks
D Holz, AR Hall, E Usukura, S Yamashiro, N Watanabe… - Elife, 2022 - elifesciences.org
Single molecule imaging has shown that part of actin disassembles within a few seconds
after incorporation into the dendritic filament network in lamellipodia, suggestive of frequent …
after incorporation into the dendritic filament network in lamellipodia, suggestive of frequent …
Reconstitution of the equilibrium state of dynamic actin networks
Principles of regulation of actin network dimensions, fundamentally important for cell
functions, remain unclear. We studied in vitro and in silico the effect of key parameters, actin …
functions, remain unclear. We studied in vitro and in silico the effect of key parameters, actin …
Models of Dendritic Actin Network Dynamics in Lamellipodial Protrusions
DM Holz - 2021 - search.proquest.com
The thin lamellipodial protrusions of crawling cells are driven by a dendritic actin filament
network. Protrusive force is generated by actin monomer polymerization at the barbed ends …
network. Protrusive force is generated by actin monomer polymerization at the barbed ends …
[图书][B] Quantitative and mechanistic aspects of Nck function in tyrosine kinase signaling to the actin cytoskeleton
JA Ditlev - 2012 - search.proquest.com
Nck, a Src homology (SH) 2/SH3 adaptor protein, functions in tyrosine kinase signaling by
linking tyrosine phosphorylation to binding partners that facilitate local actin polymerization …
linking tyrosine phosphorylation to binding partners that facilitate local actin polymerization …