Drug-induced liver injury (DILI) is a major concern for the pharmaceutical industry and
constitutes one of the most important reasons for the termination of promising drug …

Attrition due to nonclinical safety represents a major issue for the productivity of
pharmaceutical research and development (R&D) organizations, especially during the …

The purposes of acute toxicity testing are to obtain information on the biologic activity of a
chemical and gain insight into its mechanism of action. The information on acute systemic …

The study compares the toxicity of 53 selected medicinal plants commonly used in the
Philippines to treat various diseases. It uses as a benchmark Vitex negundo L., which was …

In this study, the association between the acute toxicity of 15 compounds to Daphnia magna,
expressed as 24-and 48-h LC50 values, and the corresponding oral LD50 values for the rat …

Cytotoxicity studies are a useful initial step in determining the potential toxicity of a test
substance, including plant extracts or biologically active compounds isolated from plants …

Abstract Introduction Pistacia lentiscus (Anacardiaceae) is used in Algeria for the treatment
of inflammation, burns and gastrointestinal complaints. The present work was designed to …

There is a growing interest to use in vitro BBB cell assays in early safety assessment of
compounds. By modifying a well-validated co-culture model of brain capillary endothelial …

Acute systemic toxicity testing provides the basis for hazard labeling and risk management
of chemicals. A number of international efforts have been directed at identifying non-animal …

DNA microarray technology enables genome‐wide detection of cell response at the
transcriptional level. We are planning to make bioassay systems that can detect …