Ocular drug delivery barriers—role of nanocarriers in the treatment of anterior segment ocular diseases
Ocular drug delivery is challenging due to the presence of anatomical and physiological
barriers. These barriers can affect drug entry into the eye following multiple routes of …
barriers. These barriers can affect drug entry into the eye following multiple routes of …
Nanotherapies for the treatment of ocular diseases
S Reimondez-Troitiño, N Csaba, MJ Alonso… - European Journal of …, 2015 - Elsevier
The topical route is the most frequent and preferred way to deliver drugs to the eye.
Unfortunately, the very low ocular drug bioavailability (less than 5%) associated with this …
Unfortunately, the very low ocular drug bioavailability (less than 5%) associated with this …
Controlled ocular drug delivery with nanomicelles
Many vision threatening ocular diseases such as age‐related macular degeneration (AMD),
diabetic retinopathy, glaucoma, and proliferative vitreoretinopathy may result in blindness …
diabetic retinopathy, glaucoma, and proliferative vitreoretinopathy may result in blindness …
Advances in biodegradable nano-sized polymer-based ocular drug delivery
The effective delivery of drugs to the eye remains a challenge. The eye has a myriad of
defense systems and physiological barriers that leaves ocular drug delivery systems with …
defense systems and physiological barriers that leaves ocular drug delivery systems with …
Trends in formulation approaches for sustained drug delivery to the posterior segment of the eye
The eye, an intricate organ comprising physical and physiological barriers, poses a
significant challenge for ophthalmic physicians seeking to treat serious ocular diseases …
significant challenge for ophthalmic physicians seeking to treat serious ocular diseases …
Advanced nanodelivery platforms for topical ophthalmic drug delivery
Highlights•Eye drops are applied at high frequency due to unique physio-anatomy of
corneal tissue.•Different types of nanodelivery platforms (medical devices) have been …
corneal tissue.•Different types of nanodelivery platforms (medical devices) have been …
Novel nanosystems for the treatment of ocular inflammation: Current paradigms and future research directions
L Lalu, V Tambe, D Pradhan, K Nayak, S Bagchi… - Journal of Controlled …, 2017 - Elsevier
Ocular discomforts involve anterior/posterior-segment diseases, symptomatic distress and
associated inflammations and severe retinal disorders. Conventionally, the formulations …
associated inflammations and severe retinal disorders. Conventionally, the formulations …
Soluplus micelles for acyclovir ocular delivery: Formulation and cornea and sclera permeability
A Varela-Garcia, A Concheiro… - International journal of …, 2018 - Elsevier
Nearly 20% of people affected by the herpes simplex virus (HSV) suffer from vision
problems. The virus can infect all layers of the cornea or cause inflammatory diseases of the …
problems. The virus can infect all layers of the cornea or cause inflammatory diseases of the …
New nanomicelle curcumin formulation for ocular delivery: improved stability, solubility, and ocular anti-inflammatory treatment
M Li, M Xin, C Guo, G Lin, X Wu - Drug development and industrial …, 2017 - Taylor & Francis
Context: A stable topical ophthalmic curcumin formulation with high solubility, stability, and
efficacy is needed for pharmaceutical use in clinics. Objectives: The objective of this article …
efficacy is needed for pharmaceutical use in clinics. Objectives: The objective of this article …
Nanomicellar topical aqueous drop formulation of rapamycin for back-of-the-eye delivery
The objective of this study was to develop a clear, aqueous rapamycin-loaded mixed
nanomicellar formulations (MNFs) for the back-of-the-eye delivery. MNF of rapamycin (0.2%) …
nanomicellar formulations (MNFs) for the back-of-the-eye delivery. MNF of rapamycin (0.2%) …