[HTML][HTML] History of envenoming therapy and current perspectives
MB Pucca, FA Cerni, R Janke… - Frontiers in …, 2019 - frontiersin.org
Each year, millions of humans fall victim to animal envenomings, which may either be
deadly or cause permanent disability to the effected individuals. The Nobel Prize-winning …
deadly or cause permanent disability to the effected individuals. The Nobel Prize-winning …
[HTML][HTML] The urgent need to develop novel strategies for the diagnosis and treatment of snakebites
HF Williams, HJ Layfield, T Vallance, K Patel… - Toxins, 2019 - mdpi.com
Snakebite envenoming (SBE) is a priority neglected tropical disease, which kills in excess of
100,000 people per year. Additionally, many millions of survivors also suffer through …
100,000 people per year. Additionally, many millions of survivors also suffer through …
[HTML][HTML] Oligonucleotide aptamers for pathogen detection and infectious disease control
During an epidemic or pandemic, the primary task is to rapidly develop precise diagnostic
approaches and effective therapeutics. Oligonucleotide aptamer-based pathogen detection …
approaches and effective therapeutics. Oligonucleotide aptamer-based pathogen detection …
[HTML][HTML] The search for natural and synthetic inhibitors that would complement antivenoms as therapeutics for snakebite envenoming
A global strategy, under the coordination of the World Health Organization, is being unfolded
to reduce the impact of snakebite envenoming. One of the pillars of this strategy is to ensure …
to reduce the impact of snakebite envenoming. One of the pillars of this strategy is to ensure …
[HTML][HTML] Innovative immunization strategies for antivenom development
E Bermúdez-Méndez, A Fuglsang-Madsen, S Føns… - Toxins, 2018 - mdpi.com
Snakes, scorpions, and spiders are venomous animals that pose a threat to human health,
and severe envenomings from the bites or stings of these animals must be treated with …
and severe envenomings from the bites or stings of these animals must be treated with …
[HTML][HTML] Recent advances in next generation snakebite antivenoms
C Knudsen, AH Laustsen - Tropical medicine and infectious disease, 2018 - mdpi.com
With the inclusion of snakebite envenoming on the World Health Organization's list of
Neglected Tropical Diseases, an incentive has been established to promote research and …
Neglected Tropical Diseases, an incentive has been established to promote research and …
[HTML][HTML] Exploring the utility of ssDNA aptamers directed against snake venom toxins as new therapeutics for snakebite envenoming
N Alomran, R Chinnappan, J Alsolaiss, NR Casewell… - Toxins, 2022 - mdpi.com
Snakebite is a neglected tropical disease that causes considerable death and disability in
the tropical world. Although snakebite can cause a variety of pathologies in victims …
the tropical world. Although snakebite can cause a variety of pathologies in victims …
Engineering and design considerations for next-generation snakebite antivenoms
Snakebite envenoming is a devastating Neglected Tropical Disease, the treatment of which
has seen relatively little innovation since the invention of antivenom serotherapy in 1894 …
has seen relatively little innovation since the invention of antivenom serotherapy in 1894 …
Non-SELEX isolation of DNA aptamers for the homogeneous-phase fluorescence anisotropy sensing of tau Proteins
Herein, we report for the first time the isolation of DNA aptamers directed against the whole
tau protein, an important Alzheimer's disease (AD) biomarker. Non-SELEX approach based …
tau protein, an important Alzheimer's disease (AD) biomarker. Non-SELEX approach based …
[HTML][HTML] Curses or cures: A review of the numerous benefits versus the biosecurity concerns of conotoxin research
WE Bjørn-Yoshimoto, IBL Ramiro, M Yandell… - Biomedicines, 2020 - mdpi.com
Conotoxins form a diverse group of peptide toxins found in the venom of predatory marine
cone snails. Decades of conotoxin research have provided numerous measurable scientific …
cone snails. Decades of conotoxin research have provided numerous measurable scientific …