[HTML][HTML] History of envenoming therapy and current perspectives

MB Pucca, FA Cerni, R Janke… - Frontiers in …, 2019 - frontiersin.org
Each year, millions of humans fall victim to animal envenomings, which may either be
deadly or cause permanent disability to the effected individuals. The Nobel Prize-winning …

[HTML][HTML] The urgent need to develop novel strategies for the diagnosis and treatment of snakebites

HF Williams, HJ Layfield, T Vallance, K Patel… - Toxins, 2019 - mdpi.com
Snakebite envenoming (SBE) is a priority neglected tropical disease, which kills in excess of
100,000 people per year. Additionally, many millions of survivors also suffer through …

[HTML][HTML] Oligonucleotide aptamers for pathogen detection and infectious disease control

Q Wan, X Liu, Y Zu - Theranostics, 2021 - ncbi.nlm.nih.gov
During an epidemic or pandemic, the primary task is to rapidly develop precise diagnostic
approaches and effective therapeutics. Oligonucleotide aptamer-based pathogen detection …

[HTML][HTML] The search for natural and synthetic inhibitors that would complement antivenoms as therapeutics for snakebite envenoming

JM Gutiérrez, LO Albulescu, RH Clare, NR Casewell… - Toxins, 2021 - mdpi.com
A global strategy, under the coordination of the World Health Organization, is being unfolded
to reduce the impact of snakebite envenoming. One of the pillars of this strategy is to ensure …

[HTML][HTML] Innovative immunization strategies for antivenom development

E Bermúdez-Méndez, A Fuglsang-Madsen, S Føns… - Toxins, 2018 - mdpi.com
Snakes, scorpions, and spiders are venomous animals that pose a threat to human health,
and severe envenomings from the bites or stings of these animals must be treated with …

[HTML][HTML] Recent advances in next generation snakebite antivenoms

C Knudsen, AH Laustsen - Tropical medicine and infectious disease, 2018 - mdpi.com
With the inclusion of snakebite envenoming on the World Health Organization's list of
Neglected Tropical Diseases, an incentive has been established to promote research and …

[HTML][HTML] Exploring the utility of ssDNA aptamers directed against snake venom toxins as new therapeutics for snakebite envenoming

N Alomran, R Chinnappan, J Alsolaiss, NR Casewell… - Toxins, 2022 - mdpi.com
Snakebite is a neglected tropical disease that causes considerable death and disability in
the tropical world. Although snakebite can cause a variety of pathologies in victims …

Engineering and design considerations for next-generation snakebite antivenoms

C Knudsen, L Ledsgaard, RI Dehli, S Ahmadi… - Toxicon, 2019 - Elsevier
Snakebite envenoming is a devastating Neglected Tropical Disease, the treatment of which
has seen relatively little innovation since the invention of antivenom serotherapy in 1894 …

Non-SELEX isolation of DNA aptamers for the homogeneous-phase fluorescence anisotropy sensing of tau Proteins

S Lisi, E Fiore, S Scarano, E Pascale, Y Boehman… - Analytica chimica …, 2018 - Elsevier
Herein, we report for the first time the isolation of DNA aptamers directed against the whole
tau protein, an important Alzheimer's disease (AD) biomarker. Non-SELEX approach based …

[HTML][HTML] Curses or cures: A review of the numerous benefits versus the biosecurity concerns of conotoxin research

WE Bjørn-Yoshimoto, IBL Ramiro, M Yandell… - Biomedicines, 2020 - mdpi.com
Conotoxins form a diverse group of peptide toxins found in the venom of predatory marine
cone snails. Decades of conotoxin research have provided numerous measurable scientific …