Histone modifying enzymes play critical roles in many key cellular processes and are
appealing proteins for targeting by small molecules in disease. However, while the functions …

Post-translational modifications (PTMs) by ubiquitin (Ub) are versatile, highly dynamic, and
involved in nearly all aspects of eukaryote biological function. The reversibility and …

Histone post-translational modifications (PTMs) are critical for processes such as
transcription. The more notable among these are the nonacetyl histone lysine acylation …

DNA double-strand breaks (DSBs) are harmful DNA lesions, which elicit catastrophic
consequences for genome stability if not properly repaired. DSBs can be repaired by either …

Histone H3 lysine 36 methylation (H3K36me) is a conserved histone modification deposited
by the Set2 methyltransferases. Recent findings show that over-expression or mutation of …

DNA double-strand breaks (DSBs) are highly toxic lesions that can impair cellular
homeostasis and genome stability to result in tumorigenesis for inappropriate repair …

Cytotoxic T cell differentiation is guided by epigenome adaptations, but how epigenetic
mechanisms control lymphocyte development has not been well defined. Here we show that …

Dot1 (disruptor of telomeric silencing-1, DOT1L in humans) is the only known enzyme
responsible for histone H3 lysine 79 methylation (H3K79me) and is evolutionarily conserved …

Abstract DOT 1L methylates histone H3K79 and is aberrantly regulated in MLL‐rearranged
leukemia. Inhibitors have been developed to target DOT 1L activity in leukemia, but cellular …

The histone methyltransferase Dot1 is conserved from yeast to human and methylates lysine
79 of histone H3 (H3K79) on the core of the nucleosome. H3K79 methylation by Dot1 affects …