Biomaterials: foreign bodies or tuners for the immune response?

E Mariani, G Lisignoli, RM Borzì… - International journal of …, 2019 - mdpi.com
The perspectives of regenerative medicine are still severely hampered by the host response
to biomaterial implantation, despite the robustness of technologies that hold the promise to …

Blood-Contacting Biomaterials: In Vitro Evaluation of the Hemocompatibility

M Weber, H Steinle, S Golombek, L Hann… - … in bioengineering and …, 2018 - frontiersin.org
Hemocompatibility of blood-contacting biomaterials is one of the most important criteria for
their successful in vivo applicability. Thus, extensive in vitro analyses according to ISO …

Engineered PLGA microparticles for long-term, pulsatile release of STING agonist for cancer immunotherapy

X Lu, L Miao, W Gao, Z Chen, KJ McHugh… - Science translational …, 2020 - science.org
Activation of the stimulator of interferon gene (STING) pathway within the tumor
microenvironment has been shown to generate a strong antitumor response. Although local …

The inflammatory response to extracorporeal membrane oxygenation (ECMO): a review of the pathophysiology

JE Millar, JP Fanning, CI McDonald, DF McAuley… - Critical care, 2016 - Springer
Extracorporeal membrane oxygenation (ECMO) is a technology capable of providing short-
term mechanical support to the heart, lungs or both. Over the last decade, the number of …

Osteoimmunomodulation for the development of advanced bone biomaterials

Z Chen, T Klein, RZ Murray, R Crawford, J Chang… - Materials today, 2016 - Elsevier
As direct effector cells for osteogenesis, osteoblastic cells are commonly used for evaluating
the in vitro osteogenic capacity of bone biomaterials, and the traditional biological principle …

The pathology of the foreign body reaction against biomaterials

R Klopfleisch, F Jung - … of biomedical materials research Part A, 2017 - Wiley Online Library
The healing process after implantation of biomaterials involves the interaction of many
contributing factors. Besides their in vivo functionality, biomaterials also require …

Protein interactions with polymer coatings and biomaterials

Q Wei, T Becherer, S Angioletti‐Uberti… - Angewandte Chemie …, 2014 - Wiley Online Library
Protein adsorption is considered to be the most important factor of the interaction between
polymeric biomaterials and body fluids or tissues. Water‐mediated hydrophobic and …

Nano–bio interactions in cancer: from therapeutics delivery to early detection

Y Liu, J Wang, Q Xiong, D Hornburg… - Accounts of chemical …, 2020 - ACS Publications
Conspectus Understanding the interactions between nanomaterials and biological systems
plays a pivotal role in enhancing the efficacy of nanomedicine and advancing the disease …

Biocompatibility of polymer-based biomaterials and medical devices–regulations, in vitro screening and risk-management

M Bernard, E Jubeli, MD Pungente, N Yagoubi - Biomaterials science, 2018 - pubs.rsc.org
Biomaterials play an increasing role in modern health care systems. Biocompatibility poses
a significant challenge for manufacturers of medical devices and contemporary intelligent …

[HTML][HTML] Heparin coatings for improving blood compatibility of medical devices

R Biran, D Pond - Advanced drug delivery reviews, 2017 - Elsevier
Blood contact with biomaterials triggers activation of multiple reactive mechanisms that can
impair the performance of implantable medical devices and potentially cause serious …