The novel coronavirus disease 2019 (COVID-19) caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) has spread worldwide. The main protease (M pro) of …

The time and cost of developing new drugs have led many groups to limit their search for
therapeutics to compounds that have previously been approved for human use. Many …

Antiviral therapies that impede virus entry are attractive because they act on the first phase
of the infectious cycle. Drugs that target pathways common to multiple viruses are …

Lassa hemorrhagic fever, caused by Lassa mammarenavirus (LASV) infection, accumulates
up to 5000 deaths every year. Currently, there is no vaccine available to combat this …

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for
coronavirus disease 2019 (COVID-19). Since its emergence, the COVID-19 pandemic has …

The family members of Arenaviridae include members of the genus Machupo virus, which
have bi-segmented negative sense RNA inside the envelope and can be transferred to …

Dengue and chikungunya are two important mosquito-borne infections which are known to
occur extensively in tropical and subtropical areas. Presently, there is no treatment for these …

Arenaviruses are a large family of enveloped negative-strand RNA viruses that include
several causative agents of severe hemorrhagic fevers. Currently, there are no FDA …

Neglected diseases caused by arenaviruses such as Lassa virus (LASV) and filoviruses like
Ebola virus (EBOV) primarily afflict resource-limited countries, where antiviral drug …

Hemorrhagic fevers (HF) resulting from pathogenic arenaviral infections have traditionally
been neglected as tropical diseases primarily affecting African and South American regions …