Stress is defined as an adverse condition that disturbs the homeostasis of the body and
activates adaptation responses. Among the many pathways and mediators involved …

Abstract Dipeptidyl peptidase-4 (DPP4) is a widely expressed enzyme transducing actions
through an anchored transmembrane molecule and a soluble circulating protein. Both …

Neuropeptides are important mediators both within the nervous system and between
neurons and other cell types. Neuropeptides such as substance P, calcitonin gene-related …

The gut–brain axis refers to the bidirectional communication between the gut and the brain.
Four information carriers (vagal and spinal afferent neurons, immune mediators such as …

Summary CD26/DPP4 (dipeptidyl peptidase 4/DP4/DPPIV) is a surface T cell activation
antigen and has been shown to have DPP4 enzymatic activity, cleaving-off amino-terminal …

IntroductionInflammatory bowel disease (IBD) is a chronic relapsing and remitting disorder
characterised by inflammation of the gastrointestinal tract. There is a growing consensus that …

Dipeptidyl-peptidase IV (DPP4), originally identified as an aminopeptidase in 1960s, is an
ubiquitously expressed protease presented as either a membrane-bound or soluble form …

Neuropeptide Y (NPY), one of the most abundant peptides in the nervous system, exerts its
effects via five receptor types, termed Y 1, Y 2, Y 4, Y 5 and Y 6. NPY's pleiotropic functions …

Inflammatory bowel diseases (IBD) have a complex, multifactorial pathophysiology with an
unmet need for effective treatment. This calls for novel strategies to improve disease …

Despite the bi-directional interaction between gut microbiota and the brain not being fully
understood, there is increasing evidence arising from animal and human studies that show …