Behavioral and neurobiological mechanisms of pavlovian and instrumental extinction learning

ME Bouton, S Maren, GP McNally - Physiological reviews, 2021 - journals.physiology.org
This article reviews the behavioral neuroscience of extinction, the phenomenon in which a
behavior that has been acquired through Pavlovian or instrumental (operant) learning …

Deep brain stimulation for the treatment of drug addiction

TR Wang, S Moosa, RF Dallapiazza, WJ Elias… - Neurosurgical …, 2018 - thejns.org
Drug addiction represents a significant public health concern that has high rates of relapse
despite optimal medical therapy and rehabilitation support. New therapies are needed, and …

The application of deep brain stimulation in the treatment of psychiatric disorders

I Graat, M Figee, D Denys - International Review of Psychiatry, 2017 - Taylor & Francis
Deep brain stimulation (DBS) is a last-resort treatment for neurological and psychiatric
disorders that are refractory to standard treatment. Over the last decades, the progress of …

Environmental, genetic and epigenetic contributions to cocaine addiction

RC Pierce, B Fant, SE Swinford-Jackson… - …, 2018 - nature.com
Decades of research on cocaine has produced volumes of data that have answered many
important questions about the nature of this highly addictive drug. Sadly, none of this …

Circuit selectivity in drug versus natural reward seeking behaviors

RW Nall, JA Heinsbroek, TB Nentwig… - Journal of …, 2021 - Wiley Online Library
Substance use disorder (SUD) is characterized, in part by behavior biased toward drug use
and away from natural sources of reward (eg, social interaction, food, sex). The …

Chemogenetic modulation of accumbens direct or indirect pathways bidirectionally alters reinstatement of heroin-seeking in high-but not low-risk rats

TJ O'Neal, MN Nooney, K Thien… - …, 2020 - nature.com
Opioid addiction has been declared a public health emergency, with fatal overdoses
following relapse reaching epidemic proportions and disease-associated costs continuing to …

Deep brain stimulation in drug addiction treatment: research progress and perspective

R Chang, J Peng, Y Chen, H Liao, S Zhao… - Frontiers in …, 2022 - frontiersin.org
Drug addiction is a chronic psychiatric disorder characterized by compulsive drug-seeking
and drug-using behavior, and a tremendous socioeconomic burden to society. Current …

A wide range of Deep Brain Stimulation of the nucleus accumbens shell time independently reduces the extinction period and prevents the reinstatement of …

K Eskandari, M Fattahi, E Riahi, R Khosrowabadi… - Life Sciences, 2023 - Elsevier
Methamphetamine (METH) addiction is a significant public health issue, and standard
medical therapies are often not curative. Deep Brain Stimulation (DBS) has recently shown …

Ventral tegmental area afferents and drug-dependent behaviors

I Oliva, MJ Wanat - Frontiers in psychiatry, 2016 - frontiersin.org
Drug-related behaviors in both humans and rodents are commonly thought to arise from
aberrant learning processes. Preclinical studies demonstrate that the acquisition and …

Brain stimulation in eating disorders: state of the art and future perspectives

P Duriez, R Bou Khalil, Y Chamoun, R Maatoug… - Journal of clinical …, 2020 - mdpi.com
The management of eating disorders (EDs) is still difficult and few treatments are effective.
Recently, several studies have described the important contribution of non-invasive brain …