Overview of pharmacological activities of Andrographis paniculata and its major compound andrographolide

Y Dai, SR Chen, L Chai, J Zhao, Y Wang… - Critical reviews in food …, 2019 - Taylor & Francis
Andrographis paniculata (A. paniculata) is a medicinal plant traditionally used as anti-
inflammation and anti-bacteria herb. Andrographolide, the major active component of A …

Andrographolide and its derivatives: Current achievements and future perspectives

H Zhang, S Li, Y Si, H Xu - European Journal of Medicinal Chemistry, 2021 - Elsevier
Natural product andrographolide isolated from the plant Andrographis paniculata shows a
plethora of biological activities, including anti-tumor, anti-bacterial, anti-inflammation, anti …

Andrographolide, a diterpene lactone from Andrographis paniculata and its therapeutic promises in cancer

MT Islam, ES Ali, SJ Uddin, MA Islam, S Shaw, IN Khan… - Cancer letters, 2018 - Elsevier
The diterpene lactone andrographolide, isolated from Andrographis paniculata, has been
proven to possess several important protective biological activities, including antioxidant …

Andrographolide: Chemical modification and its effect on biological activities

G Kumar, D Singh, JA Tali, D Dheer, R Shankar - Bioorganic chemistry, 2020 - Elsevier
The major natural bioactive constituent of Andrographis paniculata (AP)(Burm. f.) Nees
Andrographolide (1) and its derivatives are well acknowledged in literature for its biological …

Oxygen-and sulphur-containing heterocyclic compounds as potential anticancer agents

H Sachdeva, S Khaturia, M Saquib, N Khatik… - Applied Biochemistry …, 2022 - Springer
Oxygen-and sulphur-based heterocycles form the core structure of many biologically active
molecules as well as US FDA-approved drugs. Moreover, they possess broad range of …

Andrographolide: A natural product template for the generation of structurally and biologically diverse diterpenes

SGS Kandanur, N Tamang, NR Golakoti… - European Journal of …, 2019 - Elsevier
From times immemorial, natural products have played an important role in the management
of human health. Andrographis paniculata, belonging to the family Acanthaceae and its …

Synthesis and biological evaluation of a novel betulinic acid derivative as an inducer of apoptosis in human colon carcinoma cells (HT-29)

B Chakraborty, D Dutta, S Mukherjee, S Das… - European Journal of …, 2015 - Elsevier
A novel family of betulinic acid analogues, carrying a triazole unit at C-3 attached through a
linker, was synthesized by the application of azide-alkyne “Click reaction”. These were …

Design and synthesis of thiadiazolo-carboxamide bridged β-carboline-indole hybrids: DNA intercalative topo-IIα inhibition with promising antiproliferative activity

R Tokala, S Sana, UJ Lakshmi, P Sankarana… - Bioorganic …, 2020 - Elsevier
The conjoining of salient pharmacophoric properties directing the development of prominent
cytotoxic agents was executed by constructing thiadiazolo-carboxamide bridged β-carboline …

Metallic gold and bioactive quinacrine hybrid nanoparticles inhibit oral cancer stem cell and angiogenesis by deregulating inflammatory cytokines in p53 dependent …

SR Satapathy, A Nayak, S Siddharth, S Das… - … , Biology and Medicine, 2018 - Elsevier
Complete eradication of aggressive oral cancer remains a challenge due to the presence of
CSCs. They resist conventional chemotherapeutic agents due to their self-renewal, drug …

[HTML][HTML] The therapeutic potential of andrographolide in cancer treatment

J Hu, Y Li, X Xie, Y Song, W Yan, Y Luo… - Biomedicine & …, 2024 - Elsevier
Cancer poses a substantial global health challenge, necessitating the widespread use of
chemotherapy and radiotherapy. Despite these efforts, issues like resistance development …