Neocortical epilepsy is frequently drug-resistant. Surgery to remove the epileptogenic zone
is only feasible in a minority of cases, leaving many patients without an effective treatment …

The presubiculum (PRS) is an integral component of the perforant pathway that has recently
been recognised as a relatively unscathed region in clinical Alzheimer's disease (AD) …

Epilepsy is a comorbidity associated with Alzheimer's disease (AD), often starting many
years earlier than memory decline. Investigating this association in the early pre …

Amyloid β-protein (Aβ) pathologies have been linked to dysfunction of excitability in neurons
of the hippocampal circuit, but the molecular mechanisms underlying this process are still …

Amyloidopathy involves the accumulation of insoluble amyloid β (Aβ) species in the brain's
parenchyma and is a key histopathological hallmark of Alzheimer's disease (AD). Work on …

Accumulation of beta‐amyloid (Aβ) peptides in the human brain is a canonical pathological
hallmark of Alzheimer's disease (AD). Recent work in Aβ‐overexpressing transgenic mice …

Background: Alzheimer's disease (AD) develops undetected for years due to the lack of
early diagnostic biomarkers. In advanced AD, visual deficits related to cortical …

There is a growing consensus that Alzheimer's disease (AD) involves failure of the
homeostatic machinery, which underlies the firing stability of neural circuits. What are the …

Transgenic mice that accumulate Aβ peptides in the CNS are commonly used to interrogate
functional consequences of Alzheimer's disease-associated amyloidopathy. In addition to …

Age-dependent accumulation of amyloid-β, provoking increasing brain amyloidopathy,
triggers abnormal patterns of neuron activity and circuit synchronization in Alzheimer's …