Epidemiology and burden of dengue fever in the United States: a systematic review
LH Chen, C Marti, C Diaz Perez… - Journal of Travel …, 2023 - academic.oup.com
Background Dengue is currently a global concern. The range of dengue vectors is
expanding with climate change, yet United States of America (USA) studies on dengue …
expanding with climate change, yet United States of America (USA) studies on dengue …
Dengue virus infection and neurological manifestations: an update
Dengue virus is a flavivirus transmitted by the mosquitoes, Aedes aegypti and Aedes
albopictus. Dengue infection by all four serotypes (DEN 1 to 4) is endemic globally in …
albopictus. Dengue infection by all four serotypes (DEN 1 to 4) is endemic globally in …
Discovery of Acyl-Indole Derivatives as Pan-Serotype Dengue Virus NS4B Inhibitors
B Kesteleyn, D Bardiot, JF Bonfanti… - Journal of Medicinal …, 2023 - ACS Publications
In the absence of any approved dengue-specific treatment, the discovery and development
of a novel small-molecule antiviral for the prevention or treatment of dengue are critical. We …
of a novel small-molecule antiviral for the prevention or treatment of dengue are critical. We …
Safety, tolerability, and pharmacokinetics of JNJ-1802, a pan-serotype dengue direct antiviral small molecule, in a phase 1, double-blind, randomized, dose-escalation …
O Ackaert, F Vanhoutte, N Verpoorten… - Clinical Infectious …, 2023 - academic.oup.com
Background Dengue is a growing global health threat with no specific antiviral drugs
available for treatment or prophylaxis. This first-in-human, double-blind, randomized …
available for treatment or prophylaxis. This first-in-human, double-blind, randomized …
[HTML][HTML] Dengue virus pathogenesis and host molecular machineries
S Sinha, K Singh, YS Ravi Kumar, R Roy… - Journal of Biomedical …, 2024 - Springer
Dengue viruses (DENV) are positive-stranded RNA viruses belonging to the Flaviviridae
family. DENV is the causative agent of dengue, the most rapidly spreading viral disease …
family. DENV is the causative agent of dengue, the most rapidly spreading viral disease …
Discovery of JNJ-1802, a First-in-Class Pan-Serotype Dengue Virus NS4B Inhibitor
B Kesteleyn, JF Bonfanti, D Bardiot… - Journal of Medicinal …, 2024 - ACS Publications
Dengue is a global public health threat, with about half of the world's population at risk of
contracting this mosquito-borne viral disease. Climate change, urbanization, and global …
contracting this mosquito-borne viral disease. Climate change, urbanization, and global …
[HTML][HTML] Structure of an RNA G-quadruplex from the West Nile virus genome
JR Terrell, TT Le, A Paul, MA Brinton… - Nature …, 2024 - nature.com
Potential G-quadruplex sites have been identified in the genomes of DNA and RNA viruses
and proposed as regulatory elements. The genus Orthoflavivirus contains arthropod …
and proposed as regulatory elements. The genus Orthoflavivirus contains arthropod …
[HTML][HTML] Multiplexed multicolor antiviral assay amenable for high-throughput research
To curb viral epidemics and pandemics, antiviral drugs are needed with activity against
entire genera or families of viruses. Here, we develop a cell-based multiplex antiviral assay …
entire genera or families of viruses. Here, we develop a cell-based multiplex antiviral assay …
mRNA-encoded Cas13 can be used to treat dengue infections in mice
Dengue is a major global health threat, and there are no approved antiviral agents. Prior
research using Cas13 only demonstrated dengue mitigation in vitro. Here we demonstrate …
research using Cas13 only demonstrated dengue mitigation in vitro. Here we demonstrate …
[HTML][HTML] Pan-serotype dengue virus inhibitor JNJ-A07 targets NS4A-2K-NS4B interaction with NS2B/NS3 and blocks replication organelle formation
D Kiemel, ASH Kroell, S Denolly, U Haselmann… - Nature …, 2024 - nature.com
Dengue fever represents a significant medical and socio-economic burden in (sub) tropical
regions, yet antivirals for treatment or prophylaxis are lacking. JNJ-A07 was described as …
regions, yet antivirals for treatment or prophylaxis are lacking. JNJ-A07 was described as …