Background Dengue is currently a global concern. The range of dengue vectors is
expanding with climate change, yet United States of America (USA) studies on dengue …

Dengue virus is a flavivirus transmitted by the mosquitoes, Aedes aegypti and Aedes
albopictus. Dengue infection by all four serotypes (DEN 1 to 4) is endemic globally in …

In the absence of any approved dengue-specific treatment, the discovery and development
of a novel small-molecule antiviral for the prevention or treatment of dengue are critical. We …

Background Dengue is a growing global health threat with no specific antiviral drugs
available for treatment or prophylaxis. This first-in-human, double-blind, randomized …

Dengue viruses (DENV) are positive-stranded RNA viruses belonging to the Flaviviridae
family. DENV is the causative agent of dengue, the most rapidly spreading viral disease …

Dengue is a global public health threat, with about half of the world's population at risk of
contracting this mosquito-borne viral disease. Climate change, urbanization, and global …

Potential G-quadruplex sites have been identified in the genomes of DNA and RNA viruses
and proposed as regulatory elements. The genus Orthoflavivirus contains arthropod …

To curb viral epidemics and pandemics, antiviral drugs are needed with activity against
entire genera or families of viruses. Here, we develop a cell-based multiplex antiviral assay …

Dengue is a major global health threat, and there are no approved antiviral agents. Prior
research using Cas13 only demonstrated dengue mitigation in vitro. Here we demonstrate …

Dengue fever represents a significant medical and socio-economic burden in (sub) tropical
regions, yet antivirals for treatment or prophylaxis are lacking. JNJ-A07 was described as …