Mutations in the leucine-rich-repeat kinase 2 (LRRK2) gene are associated with familial and
sporadic cases of Parkinson's disease but are also found in immune-related disorders such …

Simple Summary The small GTPase RAB11 is a master regulator of both vesicular trafficking
and membrane dynamic defining the surface proteome of cellular membranes. As a …

Leucine-rich repeat kinase 2 (LRRK2) has been implicated in both familial and sporadic
Parkinson's disease (PD), yet its pathogenic role remains unclear. A previous screen in …

Epstein-Barr virus (EBV) causes infectious mononucleosis and is associated with multiple
human malignancies. EBV drives B-cell proliferation, which contributes to the pathogenesis …

Phagocytosis is essential for uptake and elimination of pathogenic microorganisms.
Autophagy is a highly conserved mechanism for incorporation of cellular constituents to …

Background: Efficient and controlled internalization of NPs into the cells depends on their
physicochemical properties and dynamics of the plasma membrane. NPs-cell interaction is a …

Candidiasis, aspergillosis, and mucormycosis cause the majority of nosocomial fungal
infections in immunocompromised patients. Using an unbiased transcriptional profiling in …

The surface of mammalian cells offers an interface between the cell interior and its
surrounding milieu. As part of the innate immune system, macrophages have cell surface …

In echinoderms, the coelomic epithelium (CE) is reportedly the source of new circulating
cells (coelomocytes) as well as the provider of molecular factors such as immunity-related …

Macropinocytosis is a prevalent and essential pathway in macrophages where it contributes
to anti-microbial responses and innate immune cell functions. Cell surface ruffles give rise to …