LRRK2 regulation of immune-pathways and inflammatory disease
RL Wallings, MG Tansey - Biochemical Society Transactions, 2019 - portlandpress.com
Mutations in the leucine-rich-repeat kinase 2 (LRRK2) gene are associated with familial and
sporadic cases of Parkinson's disease but are also found in immune-related disorders such …
sporadic cases of Parkinson's disease but are also found in immune-related disorders such …
[HTML][HTML] RAB11-mediated trafficking and human cancers: an updated review
Simple Summary The small GTPase RAB11 is a master regulator of both vesicular trafficking
and membrane dynamic defining the surface proteome of cellular membranes. As a …
and membrane dynamic defining the surface proteome of cellular membranes. As a …
Regulation of myeloid cell phagocytosis by LRRK2 via WAVE2 complex stabilization is altered in Parkinson's disease
KS Kim, PC Marcogliese, J Yang… - Proceedings of the …, 2018 - National Acad Sciences
Leucine-rich repeat kinase 2 (LRRK2) has been implicated in both familial and sporadic
Parkinson's disease (PD), yet its pathogenic role remains unclear. A previous screen in …
Parkinson's disease (PD), yet its pathogenic role remains unclear. A previous screen in …
[HTML][HTML] Epstein-Barr virus subverts mevalonate and fatty acid pathways to promote infected B-cell proliferation and survival
Epstein-Barr virus (EBV) causes infectious mononucleosis and is associated with multiple
human malignancies. EBV drives B-cell proliferation, which contributes to the pathogenesis …
human malignancies. EBV drives B-cell proliferation, which contributes to the pathogenesis …
[HTML][HTML] LC3-associated phagocytosis in microbial pathogenesis
S Schille, P Crauwels, R Bohn, K Bagola… - International Journal of …, 2018 - Elsevier
Phagocytosis is essential for uptake and elimination of pathogenic microorganisms.
Autophagy is a highly conserved mechanism for incorporation of cellular constituents to …
Autophagy is a highly conserved mechanism for incorporation of cellular constituents to …
Cellular uptake pathways of nanoparticles: process of endocytosis and factors affecting their fate
Background: Efficient and controlled internalization of NPs into the cells depends on their
physicochemical properties and dynamics of the plasma membrane. NPs-cell interaction is a …
physicochemical properties and dynamics of the plasma membrane. NPs-cell interaction is a …
[HTML][HTML] Comparative host transcriptome in response to pathogenic fungi identifies common and species-specific transcriptional antifungal host response pathways
M Bruno, IMW Dewi, V Matzaraki, R Ter Horst… - Computational and …, 2021 - Elsevier
Candidiasis, aspergillosis, and mucormycosis cause the majority of nosocomial fungal
infections in immunocompromised patients. Using an unbiased transcriptional profiling in …
infections in immunocompromised patients. Using an unbiased transcriptional profiling in …
The cell surface environment for pathogen recognition and entry
The surface of mammalian cells offers an interface between the cell interior and its
surrounding milieu. As part of the innate immune system, macrophages have cell surface …
surrounding milieu. As part of the innate immune system, macrophages have cell surface …
[HTML][HTML] More than a simple epithelial layer: multifunctional role of echinoderm coelomic epithelium
S Guatelli, C Ferrario, F Bonasoro, SI Anjo… - Cell and Tissue …, 2022 - Springer
In echinoderms, the coelomic epithelium (CE) is reportedly the source of new circulating
cells (coelomocytes) as well as the provider of molecular factors such as immunity-related …
cells (coelomocytes) as well as the provider of molecular factors such as immunity-related …
Rab8a localisation and activation by Toll-like receptors on macrophage macropinosomes
Macropinocytosis is a prevalent and essential pathway in macrophages where it contributes
to anti-microbial responses and innate immune cell functions. Cell surface ruffles give rise to …
to anti-microbial responses and innate immune cell functions. Cell surface ruffles give rise to …