Prenatal opioid exposure: neurodevelopmental consequences and future research priorities

E Conradt, T Flannery, JL Aschner, RD Annett… - …, 2019 - publications.aap.org
Neonatal opioid withdrawal syndrome (NOWS) has risen in prevalence from 1.2 per 1000
births in 2000 to 5.8 per 1000 births in 2012. Symptoms in neonates may include high …

Neonatal abstinence syndrome: advances in diagnosis and treatment

EM Wachman, DM Schiff, M Silverstein - Jama, 2018 - jamanetwork.com
Importance Neonatal abstinence syndrome, which occurs as a result of in utero opioid
exposure, affects between 6.0 and 20 newborns per 1000 live US births. There is substantial …

Cognitive and motor outcomes of children with prenatal opioid exposure: a systematic review and meta-analysis

SL Yeoh, J Eastwood, IM Wright, R Morton… - JAMA network …, 2019 - jamanetwork.com
Importance Prenatal opioid exposure (POE) is one of the fastest-growing global health
problems, but its association with long-term neurologic and physical development remains …

Prenatal risk factors and perinatal and postnatal outcomes associated with maternal opioid exposure in an urban, low-income, multiethnic US population

RE Azuine, Y Ji, HY Chang, Y Kim, H Ji… - JAMA network …, 2019 - jamanetwork.com
Importance The opioid epidemic increasingly affects pregnant women and developing
fetuses, resulting in high rates of neonatal abstinence syndrome. However, longitudinal …

Educational disabilities among children born with neonatal abstinence syndrome

MMA Fill, AM Miller, RH Wilkinson, MD Warren… - …, 2018 - publications.aap.org
BACKGROUND: Neonatal abstinence syndrome (NAS) is a postnatal drug withdrawal
syndrome that can occur after intrauterine opioid exposure. Adverse neurobehavioral …

Neurodevelopmental outcomes of children born to opioid-dependent mothers: a systematic review and meta-analysis

SJ Lee, S Bora, NC Austin, A Westerman… - Academic pediatrics, 2020 - Elsevier
Background Children born to opioid-dependent mothers are at risk of adverse
neurodevelopment. The magnitude of this risk remains inconclusive. Objective To conduct a …

Prenatal opioid exposure: the next neonatal neuroinflammatory disease

LL Jantzie, JR Maxwell, JC Newville… - Brain, behavior, and …, 2020 - Elsevier
The rates of opioid use disorder during pregnancy have more than quadrupled in the last
decade, resulting in numerous infants suffering exposure to opioids during the perinatal …

Cognitive and behavioral impact on children exposed to opioids during pregnancy

JJ Larson, DL Graham, LT Singer, AM Beckwith… - …, 2019 - publications.aap.org
The developmental impact of opioid use during pregnancy is a subject of ongoing debate.
Short-term neonatal outcomes, such as lower birth weight and neonatal abstinence …

Behavior and attention problems in eight-year-old children with prenatal opiate and poly-substance exposure: a longitudinal study

E Nygaard, K Slinning, V Moe, KB Walhovd - PloS one, 2016 - journals.plos.org
Multiple studies have found that children born to mothers with opioid or poly-substance use
during pregnancy have more behavior and attention problems and lower cognitive …

[HTML][HTML] Prenatal exposure to methadone or buprenorphine and long-term outcomes: a meta-analysis

JM Andersen, G Høiseth, E Nygaard - Early human development, 2020 - Elsevier
Aim To combine meta-analyses of multiple long-term outcomes in children prenatally
exposed to methadone or buprenorphine through their mothers' Opioid maintenance …